Triflupromazine

Triflupromazine (Vesprin) is an antipsychotic medication of the phenothiazine class. Among different effects of triflupromazine indication for use of this drug is severe emesis and severe Hiccups.[1] Due to its potential side effects (triflupromazine has higher risk for side effects than many other antipsychotics) it is not gold standard in antiemetic therapy.

Triflupromazine

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a600010
ATC code	N05AA05 (WHO)
Legal status
Legal status	US: ℞-only
Identifiers
IUPAC name N,N-dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-amine
CAS Number	146-54-3^Y
PubChem CID	5568
IUPHAR/BPS	4330
DrugBank	DB00508^N
ChemSpider	5367^N
UNII	RO16TQF95Y
KEGG	D00390^N
ChEBI	CHEBI:9711^N
ChEMBL	ChEMBL570^N
CompTox Dashboard (EPA)	DTXSID9023704
ECHA InfoCard	100.005.158
Chemical and physical data
Formula	C18H19F3N2S
Molar mass	352.42 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CN(C)CCCN1c2ccccc2Sc2ccc(cc12)C(F)(F)F
InChI InChI=1S/C18H19F3N2S/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3^N Key:XSCGXQMFQXDFCW-UHFFFAOYSA-N^N
^NY (what is this?)  (verify)

Serious side effects of triflupromazine can be akathisia and tardive dyskinesia as well as the rare, but potentially fatal, neuroleptic malignant syndrome.

References

1. Drug bank.ca.