Thiethylperazine

Thiethylperazine (Torecan) is an antiemetic of the phenothiazine class. Though it was never licensed or used as an antipsychotic, it may have such effects.

Thiethylperazine

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	R06AD03 (WHO)
Pharmacokinetic data
Protein binding	60%
Identifiers
IUPAC name 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
CAS Number	1420-55-9^Y
PubChem CID	5440
IUPHAR/BPS	7306
DrugBank	DB00372^Y
ChemSpider	5245^Y
UNII	8ETK1WAF6R
KEGG	D02354^Y
ChEBI	CHEBI:9544^Y
ChEMBL	ChEMBL1378^Y
CompTox Dashboard (EPA)	DTXSID1023651
ECHA InfoCard	100.014.381
Chemical and physical data
Formula	C22H29N3S2
Molar mass	399.62 g·mol^−1
3D model (JSmol)	Interactive image
SMILES S(c2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(C)CC4)CC
InChI InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3^Y Key:XCTYLCDETUVOIP-UHFFFAOYSA-N^Y
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Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice.[1]

References

1. Science Daily (September 1, 2011). "Alzheimer Disease: Transport Protein ABCC1 Plays Key Role in Clearing Beta-Amyloid from Brains of Mice". Retrieved September 1, 2011.