Histamine receptor

The histamine receptors are a class of G protein–coupled receptors which bind histamine as their primary endogenous ligand.[1]

There are four known histamine receptors:

Comparison
Histamine receptors
ReceptorMechanismFunctionAntagonists
H1 Gq
H2 Gs
↑ cAMP2+
H3 Gi
H4 Gi

There are several splice variants of H3 present in various species. Though all of the receptors are 7-transmembrane g protein coupled receptors, H1 and H2 are quite different from H3 and H4 in their activities. H1 causes an increase in PIP2 hydrolysis, H2 stimulates gastric acid secretion, and H3 mediates feedback inhibition of histamine.

gollark: Also, thaumeclipse, there's CCFuse although I don't know if it still works.
gollark: Opus, say, is a more efficient codec than DFPWM, so you could use a lower bitrate and still keep everyone happy.
gollark: <@!369987447276437523> Why not?
gollark: DFPWM? You can, LionRay does it and there's some simple C implementation.
gollark: Tape drive DFPWM en/decoding already occurs out of game, so that doesn't apply.

References
  1. Hill SJ, Ganellin CR, Timmerman H, Schwartz JC, Shankley NP, Young JM, Schunack W, Levi R, Haas HL (1997). "International Union of Pharmacology. XIII. Classification of histamine receptors". Pharmacol. Rev. 49 (3): 253–78. PMID 9311023.
  2. Hofstra CL, Desai PJ, Thurmond RL, Fung-Leung WP (2003). "Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells". J. Pharmacol. Exp. Ther. 305 (3): 1212–21. doi:10.1124/jpet.102.046581. PMID 12626656.
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