Alprenolol
Alprenolol, or alfeprol, alpheprol, and alprenololum (Gubernal, Regletin, Yobir, Apllobal, Aptine, Aptol Duriles), is a non-selective beta blocker as well as a 5-HT1A and 5-HT1B receptor antagonist,[1] used in the treatment of angina pectoris.[2] It is no longer marketed by AstraZeneca, but may still be available from other pharmaceutical companies or generically.
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Protein binding | 80% - 90% |
| Elimination half-life | 2-3 hours → 4-OH-alprenolol |
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| ECHA InfoCard | 100.033.750  |
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| Formula | C15H23NO2 |
| Molar mass | 249.354 g·mol−1 |
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References
- Langlois M, Brémont B, Rousselle D, Gaudy F (1993). "Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors". Eur. J. Pharmacol. 244 (1): 77–87. doi:10.1016/0922-4106(93)90061-d. PMID 8093601.
- Hickie JB (1970). "Alprenolol ("aptin") in angina pectoris. A double-blind multicentre trial". Med. J. Aust. 2 (6): 268–72. doi:10.5694/j.1326-5377.1970.tb49984.x. PMID 4393977.
| β, non-selective | |
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| β1-selective | |
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| α1- + β-selective | |
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