Pukateine

Pukateine is an alkaloid found in the bark of the New Zealand tree Laurelia novae-zelandiae ("Pukatea"). An extract from pukatea is used in traditional Māori herbal medicine as an analgesic,[1][2]

Pukateine

Clinical data
Other names	(R)-11-hydroxy-1,2-methylenedioxyaporphine
ATC code	none
Identifiers
IUPAC name (7aR)-7-methyl-6,7,7a,8-tetrahydro-5H-benzo[g][1,3]benzodioxolo[6,5,4-de]quinolin-12-ol
CAS Number	81-67-4^Y
PubChem CID	442340
ChemSpider	390793^N
UNII	Z9Y5O2QUPA
ChEMBL	ChEMBL258370^N
CompTox Dashboard (EPA)	DTXSID00331801
Chemical and physical data
Formula	C18H17NO3
Molar mass	295.338 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CN1CCC2=CC3=C(C4=C2[C@H]1CC5=C4C(=CC=C5)O)OCO3
InChI InChI=1S/C18H17NO3/c1-19-6-5-11-8-14-18(22-9-21-14)17-15(11)12(19)7-10-3-2-4-13(20)16(10)17/h2-4,8,12,20H,5-7,9H2,1H3/t12-/m1/s1^N Key:IKMXUUHNYQWZBC-GFCCVEGCSA-N^N
^NY (what is this?)  (verify)

Bernard Cracroft Aston studied the physical and chemical characteristics of the compound, and presented a paper with his findings to the Royal Society of New Zealand on May 11, 1909.[3]

See also

• Apomorphine
• Bulbocapnine
• Glaucine
• Nantenine
• Nuciferine
• Stepholidine
• Tetrahydropalmatine

References

1. Dajas-Bailador FA, Asencio M, Bonilla C, Scorza MC, Echeverry C, Reyes-Parada M, et al. (March 1999). "Dopaminergic pharmacology and antioxidant properties of pukateine, a natural product lead for the design of agents increasing dopamine neurotransmission". General Pharmacology. 32 (3): 373–9. doi:10.1016/s0306-3623(98)00210-9. PMID 10211594.
2. Valiente M, D'Ocon P, Noguera MA, Cassels BK, Lugnier C, Ivorra MD (July 2004). "Vascular activity of (-)-anonaine, (-)-roemerine and (-)-pukateine, three natural 6a(R)-1,2-methylenedioxyaporphines with different affinities for alpha1-adrenoceptor subtypes". Planta Medica. 70 (7): 603–9. doi:10.1055/s-2004-827181. PMID 15254852.
3. Aston BC (1909). "The Alkaloids of the Pukatea". Transactions of the Royal Society of New Zealand. 42. Retrieved October 20, 2015.