JNJ-5207852

JNJ-5207852 is a histamine antagonist selective for the H₃ subtype. It has stimulant and nootropic effects in animal studies,[1] and has been suggested as a possible treatment for memory defects associated with epilepsy.[2] JNJ-5207852 itself did not progress to clinical development due to poor pharmacokinetic characteristics, but the related compound JNJ-17216498 is currently in Phase II clinical trials for the treatment of narcolepsy.[3]

JNJ-5207852

Names
Preferred IUPAC name 1-{3-[4-(Piperidin-1-ylmethyl)phenoxy]propyl}piperidine
Systematic IUPAC name 1-({4-[3-(Piperidin-1-yl)propoxy]phenyl}methyl)piperidine
Identifiers
3D model (JSmol)	Interactive image Interactive image
Abbreviations	JNJ-5207852
ChEBI	CHEBI:312531^N
ChEMBL	ChEMBL129542^Y
ChemSpider	2046959^Y
IUPHAR/BPS	1256
MeSH	JNJ-5207852
PubChem CID	2766326
CompTox Dashboard (EPA)	DTXSID70377579
InChI InChI=1S/C20H32N2O/c1-3-12-21(13-4-1)16-7-17-23-20-10-8-19(9-11-20)18-22-14-5-2-6-15-22/h8-11H,1-7,12-18H2^Y Key: PTKHFRNHJULJKT-UHFFFAOYSA-N^Y
SMILES O(c1ccc(cc1)CN2CCCCC2)CCCN3CCCCC3 O(c1ccc(cc1)CN2CCCCC2)CCCN3CCCCC3
Properties
Chemical formula	C20H32N2O
Molar mass	316.480 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

References

1. Barbier AJ, Berridge C, Dugovic C, et al. (November 2004). "Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist". Br. J. Pharmacol. 143 (5): 649–61. doi:10.1038/sj.bjp.0705964. PMC 1575430. PMID 15466448.
2. Jia F, Kato M, Dai H, Xu A, Okuda T, Sakurai E, Okamura N, Lovenberg TW, Barbier A, Carruthers NI, Iinuma K, Yanai K (Mar 2006). "Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice". Neuropharmacology. 50 (4): 404–11. doi:10.1016/j.neuropharm.2005.09.017. PMID 16310812.
3. Esbenshade TA, Browman KE, Bitner RS, Strakhova M, Cowart MD, Brioni JD (July 2008). "The histamine H3 receptor: an attractive target for the treatment of cognitive disorders". Br. J. Pharmacol. 154 (6): 1166–81. doi:10.1038/bjp.2008.147. PMC 2483387. PMID 18469850.