Thioproperazine

Thioproperazine, sold under the brand name Majeptil, is a typical antipsychotic of the phenothiazine group which is used as a tranquilizer, antiemetic, sedative, and in the treatment of schizophrenia and manic phase of bipolar disorder.[1][2][3][4] Majeptil is available in 10 mg tablets.[5]

Thioproperazine

Names
IUPAC name N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide
Identifiers
CAS Number	316-81-4^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:59120^Y
ChEMBL	ChEMBL609109^Y
ChemSpider	9058^Y
DrugBank	DB01622^Y
ECHA InfoCard	100.005.695
KEGG	D08585^Y
PubChem CID	9429
UNII	YJ050AQ56X^Y
CompTox Dashboard (EPA)	DTXSID1023655
InChI InChI=1S/C22H30N4O2S2/c1-23(2)30(27,28)18-9-10-22-20(17-18)26(19-7-4-5-8-21(19)29-22)12-6-11-25-15-13-24(3)14-16-25/h4-5,7-10,17H,6,11-16H2,1-3H3^Y Key: VZYCZNZBPPHOFY-UHFFFAOYSA-N^Y InChI=1/C22H30N4O2S2/c1-23(2)30(27,28)18-9-10-22-20(17-18)26(19-7-4-5-8-21(19)29-22)12-6-11-25-15-13-24(3)14-16-25/h4-5,7-10,17H,6,11-16H2,1-3H3 Key: VZYCZNZBPPHOFY-UHFFFAOYAJ
SMILES CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C
Properties
Chemical formula	C22H30N4O2S2
Molar mass	446.6292 g/mol
Pharmacology
ATC code	N05AB08 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is ^YN ?)
Infobox references

Side effects

Common[6]

• Abnormal movements (extrapyramidal symptoms)
• Changes in monthly menstrual cycle (amenorrhea)
• Decreased sexual interest and/or function
• Swelling of breasts and milk production in males and females
• Difficulty sleeping
• Constipation
• Reduced amount of urine
• Dizziness
• Drowsiness
• Dry mouth
• Nausea
• Headache
• Weight changes

Rare but potentially serious adverse effects

• Decrease in white blood cell count (agranulocytosis)
• Neuroleptic Malignant Syndrome (NMS)
• Sudden cardiac death (heart attack)
• Torsades de pointes (serious heart arrhythmia)

Elderly individuals with dementia-related psychosis treated with antipsychotic medication are at an increased risk of death compared to individuals not receiving antipsychotics.

 Drug interaction

Medications for allergies (e.g., Benadryl [diphenhydramine], certain medications for sleep (e.g., lorazepam, zopiclone), certain medications for pain (e.g., fentanyl), Antiparkinson medications.

References

1. Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 1019–. ISBN 978-3-88763-075-1.
2. I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 272–. ISBN 978-94-011-4439-1.
3. https://www.drugs.com/international/thioproperazine.html
4. "Thioproperazine - Oral". Retrieved 2018-09-16.
5. "Thioproperazine". www.drugbank.ca. Retrieved 2018-09-16.
6. "Schizophrenia Society of Ontario - Majeptil (thioproperazine)". www.schizophrenia.on.ca. Retrieved 2018-09-16.