Ricasetron

Ricasetron (BRL-46470) is a drug which acts as a selective antagonist at the serotonin 5-HT₃ receptor.[1] It has antiemetic effects as with other 5-HT₃ antagonists,[2] and also has anxiolytic effects significantly stronger than other related drugs,[3] and with less side effects than benzodiazepine anxiolytics.[4][5] However, it has never been developed for medical use.

Ricasetron

Clinical data
ATC code	none
Identifiers
IUPAC name endo-N-(8-Methyl-8-azabicyclo[3.2.1]oct-3yl)-2,3-dihydro-3,3-dimethyl-indole-1-carboxamide
CAS Number	117086-68-7^Y
PubChem CID	14850173
IUPHAR/BPS	2302
ChemSpider	16736765^N
UNII	R92JB88O88
ChEMBL	ChEMBL2105377^N
Chemical and physical data
Formula	C19H27N3O
Molar mass	313.445 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CC1(CN(c2c1cccc2)C(=O)N[C@H]3C[C@H]4CC[C@@H](C3)N4C)C
InChI InChI=1S/C19H27N3O/c1-19(2)12-22(17-7-5-4-6-16(17)19)18(23)20-13-10-14-8-9-15(11-13)21(14)3/h4-7,13-15H,8-12H2,1-3H3,(H,20,23)/t13-,14+,15-^N Key:ILXWRFDRNAKTDD-QDMKHBRRSA-N^N
^NY (what is this?)  (verify)

See also

• Zatosetron
• Bemesetron
• Tropanserin
• Tropisetron
• Granisetron

References

1. Newberry NR, Watkins CJ, Sprosen TS, Blackburn TP, Grahame-Smith DG, Leslie RA (August 1993). "BRL 46470 potently antagonizes neural responses activated by 5-HT3 receptors". Neuropharmacology. 32 (8): 729–35. doi:10.1016/0028-3908(93)90180-B. PMID 8413836.
2. Bermudez J, Sanger GJ (June 1994). "Prolonged anti-emetic activity and 5-HT3-receptor antagonism by BRL 46470 in conscious ferrets". The Journal of Pharmacy and Pharmacology. 46 (6): 520–1. doi:10.1111/j.2042-7158.1994.tb03843.x. PMID 7932054.
3. Blackburn TP, Baxter GS, Kennett GA, King FD, Piper DC, Sanger GJ, Thomas DR, Upton N, Wood MD (1993). "BRL 46470A: a highly potent, selective and long acting 5-HT3 receptor antagonist with anxiolytic-like properties". Psychopharmacology. 110 (3): 257–64. doi:10.1007/BF02251279. PMID 7831418.
4. Link CG, Leigh TJ, Dennison JK (April 1993). "The effects of BRL 46470A, a novel 5-HT3 receptor antagonist, and lorazepam on psychometric performance and the EEG". British Journal of Clinical Pharmacology. 35 (4): 395–9. doi:10.1111/j.1365-2125.1993.tb04156.x. PMC 1381550. PMID 8485019.
5. de Souza Silva M, Guimarães FS, Graeff FG, Tomaz C (December 1993). "Absence of amnestic effect of an anxiolytic 5-HT3 antagonist (BRL 46470A) injected into basolateral amygdala, as opposed to diazepam". Behavioural Brain Research. 59 (1–2): 141–5. doi:10.1016/0166-4328(93)90160-R. PMID 8155281.