Phenylbiguanide

Phenylbiguanide
Legal status
Legal status	UN: Unscheduled ;
Identifiers
	IUPAC name 1-Phenylbiguanide;
CAS Number	102-02-3;
PubChem CID	4780;
ChemSpider	4616;
UNII	W8PKA3T2I3;
ChEBI	CHEBI:75377;
ChEMBL	ChEMBL13791;
CompTox Dashboard (EPA)	DTXSID90144508 ;
ECHA InfoCard	100.002.726
Chemical and physical data
Formula	C8H11N5
Molar mass	177.211 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	135–142 °C (275–288 °F)
	SMILES c1ccc(cc1)NC(=N)NC(=N)N;
	InChI InChI=1S/C8H11N5/c9-7(10)13-8(11)12-6-4-2-1-3-5-6/h1-5H,(H6,9,10,11,12,13); Key:CUQCMXFWIMOWRP-UHFFFAOYSA-N;

Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system.[1] It has been found to trigger dopamine release in the nucleus accumbens of rats.[2]

Derivatives

Phenylbiguanide is used to make amanozine and benfosformin.

gollark: Look, it has pattern matching in it, therefore good.

gollark: How SHOULD I do it?

gollark: ↑ you, as a result

gollark: ```rustfn matches(expr: &Value, condition: &Value) -> Option<Bindings> { match (expr, condition) { (Value::Num(a), Value::Num(b)) => if a == b { Some(HashMap::new()) } else { None }, (Value::Call(efn, eargs), Value::Call(rfn, rargs)) => { if efn != rfn { return None } if rargs.len() != eargs.len() { return None } let mut out_bindings = HashMap::new(); for (rarg, earg) in rargs.iter().zip(eargs) { match matches(earg, rarg) { Some(x) => out_bindings.extend(x), None => return None } } Some(out_bindings) }, (_, Value::Identifier(b)) => Some(vec![(b.clone(), expr.clone())].into_iter().collect()), _ => None }}```

gollark: You fell right into my trap, actually.

References

Higgins GA, Joharchi N, Sellers EM (March 1993). "Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats". The Journal of Pharmacology and Experimental Therapeutics. Journal of Pharmacology and Experimental Therapeutics. 264 (3): 1440–9. PMID 8450478.
Chen JP, van Praag HM, Gardner EL (March 1991). "Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens". Brain Research. Brain Research. 543 (2): 354–7. doi:10.1016/0006-8993(91)90050-6. PMID 1711914.

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[1] Higgins GA, Joharchi N, Sellers EM (March 1993). "Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats". The Journal of Pharmacology and Experimental Therapeutics. Journal of Pharmacology and Experimental Therapeutics. 264 (3): 1440–9. PMID 8450478.

[2] Chen JP, van Praag HM, Gardner EL (March 1991). "Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens". Brain Research. Brain Research. 543 (2): 354–7. doi:10.1016/0006-8993(91)90050-6. PMID 1711914.