Benperidol
Benperidol, sold under the trade name Anquil[1] among others, is a drug which is a highly potent butyrophenone derivative. It is the most potent neuroleptic on the European market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to haloperidol).[2] It is an antipsychotic, which can be used for the treatment of schizophrenia,[3] but it is primarily used to control hypersexuality syndromes[4] and is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone acetate.[5]
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| Trade names | Anquil, Frenactil |
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| Routes of administration | Oral |
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| ECHA InfoCard | 100.016.521  |
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| Formula | C22H24FN3O2 |
| Molar mass | 381.451 g·mol−1 |
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Benperidol was discovered at Janssen Pharmaceutica in 1961.
Synthesis
Benperidol synthesis:[6]
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See also
- Timiperone has the same structure but thiourea instead of normal urea.
- Pimozide & Bezitramide (& Oxiperomide & Neflumozide) are also made from 4-(1-Benzimidazolinone)piperidine precursor
- Droperidol is self-same albeit with a tetrahydropyridine ring.
References
- "Benperidol - a drug for sexual offenders?". Drug and Therapeutics Bulletin. BMJ Publishing Group Ltd. 12: 12. 1974-02-01.
- Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German)
- Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.
- British National Formulary (49th), British Medical Association 2005 p 183
- Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.
- BE 626307 (1963 to Janssen), C.A. 60, 10690c (1964), corresp. to GB 989755.
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