NNC 38-1049

NNC 38-1049 is a histamine antagonist selective for the H₃ subtype. It has anorectic effects in animal studies and is being researched as a potential treatment for obesity.[1][2]

NNC 38-1049

Names
IUPAC name 1-(4-chlorophenyl)-4-(4-cyclopentylpiperazine-1-yl)-4-oxobutan-1-one
Identifiers
CAS Number	757183-18-9^Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL97170^Y
ChemSpider	7974195^Y
PubChem CID	9798429
CompTox Dashboard (EPA)	DTXSID70430911
InChI InChI=1S/C19H25ClN2O2/c20-16-7-5-15(6-8-16)18(23)9-10-19(24)22-13-11-21(12-14-22)17-3-1-2-4-17/h5-8,17H,1-4,9-14H2^Y Key: VPARRMQGLNFBBR-UHFFFAOYSA-N^Y InChI=1/C19H25ClN2O2/c20-16-7-5-15(6-8-16)18(23)9-10-19(24)22-13-11-21(12-14-22)17-3-1-2-4-17/h5-8,17H,1-4,9-14H2 Key: VPARRMQGLNFBBR-UHFFFAOYAT
SMILES Clc1ccc(cc1)C(=O)CCC(=O)N3CCN(C2CCCC2)CC3
Properties
Chemical formula	C19H25ClN2O2
Molar mass	348.866 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is ^YN ?)
Infobox references

References

1. Malmlöf K, Zaragoza F, Golozoubova V, et al. (December 2005). "Influence of a selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight". Int J Obes (Lond). 29 (12): 1402–12. doi:10.1038/sj.ijo.0803036. PMID 16151415.
2. Malmlöf K, Golozoubova V, Peschke B, Wulff BS, Refsgaard HH, Johansen PB, Cremers T, Rimvall K (Dec 2006). "Increase of neuronal histamine in obese rats is associated with decreases in body weight and plasma triglycerides". Obesity (Silver Spring). 14 (12): 2154–62. doi:10.1038/oby.2006.252. PMID 17189541.