SCH-23390

SCH-23390
Names
	IUPAC name 7-chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol
Identifiers
CAS Number	87075-17-0 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:73297 ;
ChEMBL	ChEMBL62 ;
IUPHAR/BPS	943;
PubChem CID	5018;
UNII	UGT5535REQ ;
CompTox Dashboard (EPA)	DTXSID60873373 DTXSID40873376, DTXSID60873373 ;
	SMILES CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)Cl;
Properties
Chemical formula	C17H18ClNO
Molar mass	287.78 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

SCH-23390 also known as halobenzazepine, is a synthetic compound that acts as a D₁ receptor antagonist and has either minimal or negligible effects on the D₂ receptor.

In a 1990 study in rats SCH-23390 offered significant protection from death in dextroamphetamine overdosage, without providing protection from death by methamphetamine overdose. The compound provided significant protection from cocaine overdose in rats only at the lowest dose tested in the measurement series. This suggested that D-amphetamine and methamphetamine at high (lethal) doses have different mechanisms of toxicity in rats.[1]

References

Derlet, R. W.; Albertson, T. E.; Rice, P. (1990). "The Effect of SCH 23390 Against Toxic Doses of Cocaine, d-Amphetamine and Methamphetamine". Life Sciences. 47 (9): 821–827. doi:10.1016/0024-3205(90)90555-6. PMID 2215083.

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[1] Derlet, R. W.; Albertson, T. E.; Rice, P. (1990). "The Effect of SCH 23390 Against Toxic Doses of Cocaine, d-Amphetamine and Methamphetamine". Life Sciences. 47 (9): 821–827. doi:10.1016/0024-3205(90)90555-6. PMID 2215083.