Oxotremorine

Oxotremorine is a drug that acts as a selective muscarinic acetylcholine receptor agonist.[1]

Oxotremorine

Clinical data
Pregnancy category	C
Routes of administration	Oral, intravenous
ATC code	none
Legal status
Legal status	US: Experimental/not yet approved
Identifiers
IUPAC name 1-(4-Pyrrolidin-1-ylbut-2-yn-1-yl)pyrrolidin-2-one
CAS Number	70-22-4^Y
IUPHAR/BPS	302
ChemSpider	4469^N
UNII	5RY0UWH1JL
ChEMBL	ChEMBL7634^N
CompTox Dashboard (EPA)	DTXSID10220252
ECHA InfoCard	100.000.662
Chemical and physical data
Formula	C12H18N2O
Molar mass	206.28 g·mol^−1
3D model (JSmol)	Interactive image
SMILES C1CCN(C1)CC#CCN2CCCC2=O
InChI InChI=InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2^N Key:RSDOPYMFZBJHRL-UHFFFAOYSA-N^N
^NY (what is this?)  (verify)

Oxotremorine produces ataxia, tremor and spasticity, similar to those symptoms seen in Parkinsonism, and has thus become a research tool in experimental studies aimed at determining more effective anti-Parkinsonian drugs.[2]

Oxotremorine also produces antipsychotic effects.[3]

References

1. Tang C, Castoldi AF, Costa LG (April 1993). "Effects of the muscarinic agonist oxotremorine on membrane fluidity in rat lymphocytes". Biochem. Mol. Biol. Int. 29 (6): 1047–54. PMID 8330013.
2. Craig, C. R.; Stitzel, R. E. (2004). Modern Pharmacology. Boston: Little, Brown. p. 149.
3. http://cat.inist.fr/?aModele=afficheN&cpsidt=20678587

See also

• Tremorine