GSK-789,472

GSK-789,472
Clinical data
ATC code	none;
Identifiers
	IUPAC name 4,5-dihydro-1-phenyl-3-(piperidin-2-yl)methylimidazol-2(1H)one;
CAS Number	1257326-24-1;
ChemSpider	59650715;
Chemical and physical data
Formula	C15H21N3O
Molar mass	259.353 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1N(CC2NCCCC2)CCN1C3=CC=CC=C3;
	InChI InChI=1S/C15H21N3O/c19-15-17(12-13-6-4-5-9-16-13)10-11-18(15)14-7-2-1-3-8-14/h1-3,7-8,13,16H,4-6,9-12H2; Key:MGPOBHIJMZQPIK-UHFFFAOYSA-N;
	(verify)

GSK-789,472 is a drug which acts as both a potent and selective partial agonist at the dopamine receptor D₂, as well as an antagonist at the related D₃ subtype, but with good selectivity over D₄ and other unrelated receptors.[1]

References

Holmes IP, Blunt RJ, Lorthioir OE, Blowers SM, Gribble A, Payne AH, Stansfield IG, Wood M, Woollard PM, Reavill C, Howes CM, Micheli F, Di Fabio R, Donati D, Terreni S, Hamprecht D, Arista L, Worby A, Watson SP (March 2010). "The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure". Bioorganic & Medicinal Chemistry Letters. 20 (6): 2013–6. doi:10.1016/j.bmcl.2010.01.090. PMID 20153647.

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[pmid20153647-1] Holmes IP, Blunt RJ, Lorthioir OE, Blowers SM, Gribble A, Payne AH, Stansfield IG, Wood M, Woollard PM, Reavill C, Howes CM, Micheli F, Di Fabio R, Donati D, Terreni S, Hamprecht D, Arista L, Worby A, Watson SP (March 2010). "The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure". Bioorganic & Medicinal Chemistry Letters. 20 (6): 2013–6. doi:10.1016/j.bmcl.2010.01.090. PMID 20153647.