Buflomedil
Buflomedil is a vasoactive drug used to treat claudication or the symptoms of peripheral arterial disease. It is currently not approved by the Food and Drug Administration (FDA) for use in the United States. Currently available as trade name tablet Loftyl
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| Names | |
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| IUPAC name
4-(pyrrolidin-1-yl)-1-(2,4,6-trimethoxyphenyl)butan-1-one | |
| Identifiers | |
3D model (JSmol) |
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| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.054.393 |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C17H25NO4 | |
| Molar mass | 307.38 g/mol |
| Pharmacology | |
| C04AX20 (WHO) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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| Infobox references | |
Toxicity
This drug has been suspended from marketing in the European Union, because of concerns about severe neurological and cardiac toxicity.[1][2] In its press release dated 17 November 2011 EMA suggested that doctors "should stop using buflomedil and consider alternative treatment options". The European Commission advised all member states to revoke marketing authorisation.[3]
Various adverse effects have been reported to the FDA.[4]
gollark: It would probably help if you explain:- what you're trying to do- what web framework and language you're using- what this application actually is
gollark: > For example, on POSIX:> `path.normalize('/foo/bar//baz/asdf/quux/..');`> `// Returns: '/foo/bar/baz/asdf'`
gollark: > The path.normalize() method normalizes the given path, resolving '..' and '.' segments.
gollark: node.js calls it "normalizing", which is probably the word I meant, see here: https://nodejs.org/api/path.html#path_path_normalize_path
gollark: It should use the same filepath parsing logic as the actual filesystem, so that shouldn't be an issue.
References
- Medscape: http://www.medscape.com/viewarticle/753768
- EMA: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/public_health_alerts/2011/11/human_pha_detail_000045.jsp&mid=WC0b01ac058001d126
- https://www.bfarm.de/SharedDocs/Downloads/DE/Arzneimittel/Pharmakovigilanz/Risikoinformationen/RisikoBewVerf/a-f/buflomedil_durchf_beschluss.pdf?__blob=publicationFile&v=3
- http://www.drugcite.com/?q=BUFLOMEDIL&s=&a=
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