TRPM6

TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia.[5]

TRPM6
Identifiers
Aliases	TRPM6, CHAK2, HMGX, HOMG, HOMG1, HSH, transient receptor potential cation channel subfamily M member 6
External IDs	OMIM: 607009 MGI: 2675603 HomoloGene: 9767 GeneCards: TRPM6
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.13 Start 74,722,495 bp[1] End 74,888,094 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 B Start 18,749,983 bp[2] End 18,892,511 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • ion channel activity • GO:0001948 protein binding • cation channel activity • ATP binding • calcium channel activity Cellular component • integral component of membrane • membrane • cell membrane • brush border membrane • apical plasma membrane Biological process • phosphorylation • metal ion transport • cation transport • ion transport • protein tetramerization • protein phosphorylation • calcium ion transmembrane transport • response to toxic substance • calcium ion transport • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	140803	225997
Ensembl	ENSG00000119121	ENSMUSG00000024727
UniProt	Q9BX84	Q8CIR4
RefSeq (mRNA)	NM_001177310 NM_001177311 NM_017662	NM_153417
RefSeq (protein)	NP_001170781 NP_001170782 NP_060132	NP_700466
Location (UCSC)	Chr 9: 74.72 – 74.89 Mb	Chr 19: 18.75 – 18.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• TRPM
• Ruthenium red

References

1. GRCh38: Ensembl release 89: ENSG00000119121 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024727 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schlingmann KP, Weber S, Peters M, et al. (2002). "Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family". Nat. Genet. 31 (2): 166–70. doi:10.1038/ng889. PMID 12032568.

Further reading

• Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6.
• Chubanov V, Gudermann T, Schlingmann KP (2006). "Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis". Pflügers Arch. 451 (1): 228–34. doi:10.1007/s00424-005-1470-y. PMID 16075242.
• Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
• Bödding M (2007). "TRPM6: A Janus-like protein". Handb Exp Pharmacol. 179 (179): 299–311. doi:10.1007/978-3-540-34891-7_18. PMID 17217065.

External links

• TRPM6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.