CACNA1I

Calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Cav3.3 is a protein which in humans is encoded by the CACNA1I gene.[5][6][7]

CACNA1I
Identifiers
AliasesCACNA1I, Cav3.3, ca(v)3.3, calcium voltage-gated channel subunit alpha1 I
External IDsOMIM: 608230 MGI: 2178051 HomoloGene: 69331 GeneCards: CACNA1I
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.1Start39,570,753 bp[1]
End39,689,735 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8911

239556

Ensembl

ENSG00000100346

ENSMUSG00000022416

UniProt

Q9P0X4

n/a

RefSeq (mRNA)

NM_001003406
NM_021096

NM_001044308

RefSeq (protein)

NP_001003406
NP_066919

n/a

Location (UCSC)Chr 22: 39.57 – 39.69 MbChr 15: 80.29 – 80.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Voltage-dependent calcium channels can be distinguished based on their voltage-dependence, deactivation, and single-channel conductance. Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing.[5]

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See also

References
  1. GRCh38: Ensembl release 89: ENSG00000100346 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022416 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1I subunit".
  6. Mittman S, Guo J, Emerick MC, Agnew WS (July 1999). "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit". Neurosci. Lett. 269 (3): 121–4. doi:10.1016/S0304-3940(99)00319-5. PMID 10454147.
  7. Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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