KCNH4

Potassium voltage-gated channel subfamily H member 4 is a protein that in humans is encoded by the KCNH4 gene.[5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit.[5][6]

KCNH4
Identifiers
Aliases	KCNH4, BEC2, ELK1, Kv12.3, potassium voltage-gated channel subfamily H member 4
External IDs	OMIM: 604528 MGI: 2156184 HomoloGene: 8180 GeneCards: KCNH4
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,156,891 bp[1] End 42,181,142 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.57 cM Start 100,740,376 bp[2] End 100,759,942 bp[2]
Gene ontology Molecular function • voltage-gated ion channel activity • ion channel activity • phosphorelay sensor kinase activity • potassium channel activity • voltage-gated potassium channel activity Cellular component • integral component of membrane • intracellular • cell membrane • voltage-gated potassium channel complex • membrane • integral component of plasma membrane Biological process • ion transport • phosphorelay signal transduction system • signal transduction by protein phosphorylation • potassium ion transmembrane transport • potassium ion transport • regulation of ion transmembrane transport • transmembrane transport • regulation of membrane potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23415	380728
Ensembl	ENSG00000089558	ENSMUSG00000035355
UniProt	Q9UQ05	A2A5F7
RefSeq (mRNA)	NM_012285	NM_001081194
RefSeq (protein)	NP_036417	NP_001074663
Location (UCSC)	Chr 17: 42.16 – 42.18 Mb	Chr 11: 100.74 – 100.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000089558 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035355 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miyake A, Mochizuki S, Yokoi H, Kohda M, Furuichi K (Sep 1999). "New ether-a-go-go K(+) channel family members localized in human telencephalon". J Biol Chem. 274 (35): 25018–25. doi:10.1074/jbc.274.35.25018. PMID 10455180.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.

Further reading

• Zou A, Lin Z, Humble M, et al. (2003). "Distribution and functional properties of human KCNH8 (Elk1) potassium channels". Am. J. Physiol., Cell Physiol. 285 (6): C1356–66. CiteSeerX 10.1.1.196.6556. doi:10.1152/ajpcell.00179.2003. PMID 12890647.

External links

• Kv12.3+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNH4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)