SCN4B

Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels.[5] The protein is encoded by the SCN4B gene.[6] Mutations in the SCN4B are associated with long QT syndrome.[7]

SCN4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MZ2, 4MZ3
Identifiers
Aliases	SCN4B, ATFB17, LQT10, Navbeta4, sodium voltage-gated channel beta subunit 4
External IDs	OMIM: 608256 MGI: 2687406 HomoloGene: 18384 GeneCards: SCN4B
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 118,133,377 bp[1] End 118,152,888 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.2 Start 45,138,395 bp[2] End 45,154,152 bp[2]
Gene ontology Molecular function • sodium channel regulator activity • ion channel binding • sodium channel activity • voltage-gated ion channel activity • voltage-gated sodium channel activity involved in cardiac muscle cell action potential • voltage-gated sodium channel activity Cellular component • voltage-gated sodium channel complex • integral component of membrane • membrane • intercalated disc • intrinsic component of plasma membrane • cell membrane Biological process • cardiac muscle contraction • sodium ion transmembrane transport • sodium ion transport • regulation of ion transmembrane transport • cardiac muscle cell action potential involved in contraction • ion transport • regulation of sodium ion transmembrane transporter activity • positive regulation of sodium ion transport • AV node cell action potential • regulation of heart rate by cardiac conduction • membrane depolarization during cardiac muscle cell action potential • regulation of ventricular cardiac muscle cell membrane repolarization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6330	399548
Ensembl	ENSG00000177098	ENSMUSG00000046480
UniProt	Q8IWT1	Q7M729
RefSeq (mRNA)	NM_001142348 NM_001142349 NM_174934	NM_001013390
RefSeq (protein)	NP_001135820 NP_001135821 NP_777594	NP_001013408
Location (UCSC)	Chr 11: 118.13 – 118.15 Mb	Chr 9: 45.14 – 45.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

SCN4B might additionally function as a cell adhesion molecule.[8][9]

See also

• Sodium channel

References

1. GRCh38: Ensembl release 89: ENSG00000177098 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046480 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lewis, Amanda H.; Raman, Indira M. (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology. 592 (22): 4825–4838. doi:10.1113/jphysiol.2014.277582. ISSN 1469-7793. PMC 4259529. PMID 25172941.
6. "Entrez Gene: sodium channel".
7. Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–42. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.
8. Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.
9. Shimizu, Hideaki (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion". J Biol Chem. 27 (32): 13428–13440. doi:10.1074/jbc.M117.786509. PMC 5555201. PMID 28655765.

• Delgado P, GarcÃa-Zueco JC, Rubio-Félix D, Giralt M (1992). "[Idiopathic thrombocytopenic purpura: present knowledge and future expectations]". Sangre. 37 (6): 449–56. PMID 1293796.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Yu FH, Westenbroek RE, Silos-Santiago I, et al. (2003). "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2". J. Neurosci. 23 (20): 7577–85. doi:10.1523/JNEUROSCI.23-20-07577.2003. PMID 12930796.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Webb J, Wu FF, Cannon SC (2009). "Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit". Pflügers Arch. 457 (6): 1253–63. doi:10.1007/s00424-008-0600-8. PMC 6207185. PMID 18941776.
• Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.

External links

• Overview of all the structural information available in the PDB for UniProt: Q8IWT1 (Human Sodium channel subunit beta-4 (SCN4B)) at the PDBe-KB.