TRPM3

Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the TRPM3 gene.[5]

TRPM3
Identifiers
Aliases	TRPM3, GON-2, LTRPC3, MLSN2, transient receptor potential cation channel subfamily M member 3
External IDs	OMIM: 608961 MGI: 2443101 HomoloGene: 62287 GeneCards: TRPM3
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.12-q21.13 Start 70,529,063 bp[1] End 71,446,904 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 B Start 22,139,046 bp[2] End 22,995,410 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ion channel activity • calcium activated cation channel activity • cation channel activity • calcium channel activity Cellular component • integral component of membrane • cell membrane • membrane Biological process • detection of temperature stimulus • ion transport • protein tetramerization • sensory perception of temperature stimulus • calcium ion transport • ion transmembrane transport • cation transport • transmembrane transport • calcium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80036	226025
Ensembl	ENSG00000083067	ENSMUSG00000052387
UniProt	Q9HCF6	n/a
RefSeq (mRNA)	NM_001007470 NM_001007471 NM_020952 NM_024971 NM_206944 NM_206945 NM_206946 NM_206947 NM_206948 NM_001366141 NM_001366142 NM_001366143 NM_001366144 NM_001366145 NM_001366146 NM_001366147 NM_001366148 NM_001366149 NM_001366150 NM_001366151 NM_001366152 NM_001366153 NM_001366154	NM_001035239 NM_001035240 NM_001035241 NM_001035242 NM_001035243 NM_001035244 NM_001035245 NM_001035246 NM_177341 NM_001362487 NM_001362488 NM_001362489 NM_001362490 NM_001362491 NM_001362496 NM_001362497 NM_001362498 NM_001362499 NM_001362500 NM_001362501 NM_001362502 NM_001362503 NM_001362504 NM_001362505 NM_001362506 NM_001362507 NM_001362508 NM_001362511 NM_001362512 NM_001362513
RefSeq (protein)	NP_001007471 NP_001007472 NP_066003 NP_079247 NP_996827 NP_996828 NP_996829 NP_996830 NP_996831 NP_001353070 NP_001353071 NP_001353072 NP_001353073 NP_001353074 NP_001353075 NP_001353076 NP_001353077 NP_001353078 NP_001353079 NP_001353080 NP_001353081 NP_001353082 NP_001353083	n/a
Location (UCSC)	Chr 9: 70.53 – 71.45 Mb	Chr 19: 22.14 – 23 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been -identified.[6] TRPM3 was shown to be activated by the neurosteroid pregnenolone sulphate in pancreatic beta cell. The activation causes calcium influx and subsequent insulin release, therefore it is suggested that TRPM3 modulates glucose homeostasis.[7]

TRPM3 Ligands

Channel Blockers

1. Mefenamic acid[8]
2. Citrus fruit flavonoids, E.g. Naringenin and hesperetin, as well as Ononetin (a deoxybenzoin).[9]

Agonist

• CIM0216

See also

• TRPM

References

1. GRCh38: Ensembl release 89: ENSG00000083067 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052387 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
6. "Entrez Gene: TRPM3 transient receptor potential cation channel, subfamily M, member 3".
7. Wagner TF, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, Düfer M, Lis A, Flockerzi V, Philipp SE, Oberwinkler J (December 2008). "Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells". Nature Cell Biology. 10 (12): 1421–30. doi:10.1038/ncb1801. PMID 18978782.
8. Klose C, Straub I, Riehle M, Ranta F, Krautwurst D, Ullrich S, Meyerhof W, Harteneck C (April 2011). "Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3". British Journal of Pharmacology. 162 (8): 1757–69. doi:10.1111/j.1476-5381.2010.01186.x. PMC 3081119. PMID 21198543.
9. Straub I, Mohr F, Stab J, Konrad M, Philipp SE, Oberwinkler J, Schaefer M (April 2013). "Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3". British Journal of Pharmacology. 168 (8): 1835–50. doi:10.1111/bph.12076. PMC 3623054. PMID 23190005.

Further reading

• Oberwinkler J, Phillipp SE (2007). "TRPM3". Handbook of Experimental Pharmacology. 179 (179): 253–67. doi:10.1007/978-3-540-34891-7_15. PMID 17217062.
• Harteneck C, Reiter B (February 2007). "TRP channels activated by extracellular hypo-osmoticity in epithelia". Biochemical Society Transactions. 35 (Pt 1): 91–5. doi:10.1042/BST0350091. PMID 17233610.
• Held K, Voets T, Vriens J (2014). "TRPM3 in temperature sensing and beyond". Temperature. 2 (2): 201–13. doi:10.4161/23328940.2014.988524. PMC 4844244. PMID 27227024.
• Islam, Md. Shahidul, ed. (2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. 704. New York: Springer Science+Business Media. doi:10.1007/978-94-007-0265-3. ISBN 978-94-007-0265-3. ISSN 2214-8019. OCLC 710148029.CS1 maint: ref=harv (link)

External links

• TRPM3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.