KCNH6

Potassium voltage-gated channel subfamily H member 6 is a protein that in humans is encoded by the KCNH6 gene.[5] The protein encoded by this gene is a voltage-gated potassium channel subunit.[5]

KCNH6
Identifiers
Aliases	KCNH6, ERG-2, ERG2, HERG2, Kv11.2, hERG-2, potassium voltage-gated channel subfamily H member 6
External IDs	OMIM: 608168 MGI: 2684139 HomoloGene: 32740 GeneCards: KCNH6
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.3 Start 63,523,334 bp[1] End 63,548,977 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 106,008,124 bp[2] End 106,034,549 bp[2]
Gene ontology Molecular function • voltage-gated potassium channel activity • ion channel activity • potassium channel activity • voltage-gated ion channel activity Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane Biological process • regulation of membrane potential • potassium ion transport • regulation of ion transmembrane transport • ion transport • transmembrane transport • potassium ion transmembrane transport • regulation of heart rate by cardiac conduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81033	192775
Ensembl	ENSG00000173826	ENSMUSG00000001901
UniProt	Q9H252	n/a
RefSeq (mRNA)	NM_001278919 NM_001278920 NM_030779 NM_173092	NM_001037712
RefSeq (protein)	NP_001265848 NP_001265849 NP_110406 NP_775115	n/a
Location (UCSC)	Chr 17: 63.52 – 63.55 Mb	Chr 11: 106.01 – 106.03 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000173826 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001901 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ganetzky B, Robertson GA, Wilson GF, et al. (1999). "The eag family of K+ channels in Drosophila and mammals". Ann. N. Y. Acad. Sci. 868: 356–69. doi:10.1111/j.1749-6632.1999.tb11297.x. PMID 10414305.
• Bauer CK, Wulfsen I, Schäfer R, et al. (2003). "HERG K(+) currents in human prolactin-secreting adenoma cells". Pflügers Arch. 445 (5): 589–600. doi:10.1007/s00424-002-0980-0. PMID 12634931.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

External links

• Kv11.2+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNH6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)