KCNIP1

K_v channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene.[5][6]

KCNIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S1E, 2I2R, 2NZ0
Identifiers
Aliases	KCNIP1, KCHIP1, VABP, potassium voltage-gated channel interacting protein 1
External IDs	OMIM: 604660 MGI: 1917607 HomoloGene: 22824 GeneCards: KCNIP1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.1 Start 170,353,487 bp[1] End 170,736,632 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A4 Start 33,629,339 bp[2] End 33,993,152 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • potassium channel regulator activity • potassium channel activity • GO:0001948 protein binding • metal ion binding • voltage-gated ion channel activity Cellular component • cytoplasm • extrinsic component of cytoplasmic side of plasma membrane • voltage-gated potassium channel complex • cell membrane • cell projection • dendrite • membrane Biological process • potassium ion transport • regulation of ion transmembrane transport • ion transport • regulation of potassium ion transmembrane transport • potassium ion transmembrane transport • cardiac conduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	30820	70357
Ensembl	ENSG00000182132	ENSMUSG00000053519
UniProt	Q9NZI2	Q9JJ57
RefSeq (mRNA)	NM_001034837 NM_001034838 NM_001278339 NM_001278340 NM_014592	NM_001190885 NM_001190886 NM_001290690 NM_027398 NM_001363115
RefSeq (protein)	NP_001030009 NP_001030010 NP_001265268 NP_001265269 NP_055407	NP_001177814 NP_001177815 NP_001277619 NP_081674 NP_001350044
Location (UCSC)	Chr 5: 170.35 – 170.74 Mb	Chr 11: 33.63 – 33.99 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the family of voltage-gated potassium (K_v) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native K_v4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[6]

See also

• Voltage-gated potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000182132 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053519 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–556. Bibcode:2000Natur.403..553A. doi:10.1038/35000592. PMID 10676964.
6. "Entrez Gene: KCNIP1 Kv channel interacting protein 1".
7. Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Further reading

• Bähring R, Dannenberg J, Peters HC, et al. (2001). "Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating". J. Biol. Chem. 276 (26): 23888–23894. doi:10.1074/jbc.M101320200. PMID 11287421.
• Nakamura TY, Nandi S, Pountney DJ, et al. (2001). "Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2". FEBS Lett. 499 (3): 205–209. doi:10.1016/S0014-5793(01)02560-1. PMID 11423117.
• Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–3170. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shibata R, Misonou H, Campomanes CR, et al. (2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels". J. Biol. Chem. 278 (38): 36445–36454. doi:10.1074/jbc.M306142200. PMID 12829703.
• Van Hoorick D, Raes A, Keysers W, et al. (2004). "Differential modulation of Kv4 kinetics by KCHIP1 splice variants". Mol. Cell. Neurosci. 24 (2): 357–366. doi:10.1016/S1044-7431(03)00174-X. PMID 14572458.
• Scannevin RH, Wang K, Jow F, et al. (2004). "Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1". Neuron. 41 (4): 587–598. doi:10.1016/S0896-6273(04)00049-2. PMID 14980207.
• Lin YL, Lin SR, Wu TT, Chang LS (2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins". Biochem. Biophys. Res. Commun. 319 (3): 720–724. doi:10.1016/j.bbrc.2004.05.064. PMID 15184042.
• Lin YL, Chen CY, Cheng CP, Chang LS (2004). "Protein-protein interactions of KChIP proteins and Kv4.2". Biochem. Biophys. Res. Commun. 321 (3): 606–610. doi:10.1016/j.bbrc.2004.07.006. PMID 15358149.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pruunsild P, Timmusk T (2005). "Structure, alternative splicing, and expression of the human and mouse KCNIP gene family". Genomics. 86 (5): 581–593. doi:10.1016/j.ygeno.2005.07.001. PMID 16112838.
• Pioletti M, Findeisen F, Hura GL, Minor DL (2007). "Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer". Nat. Struct. Mol. Biol. 13 (11): 987–995. doi:10.1038/nsmb1164. PMC 3018330. PMID 17057713.CS1 maint: multiple names: authors list (link)
• Hasdemir B, Fitzgerald DJ, Prior IA, Tepikin AV, Burgoyne RD (2005). "Traffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathway". J. Cell Biol. 171 (3): 459–469. doi:10.1083/jcb.200506005. PMC 2171252. PMID 16260497.
• Venn N, Haynes LP, Burgoyne RD (2008). "Specific effects of KChIP3/calsenilin/DREAM but not KChIPs1, 2 and 4 on calcium signalling and regulated secretion in PC12 cells". Biochem. J. 413 (1): 71–80. doi:10.1042/BJ20080441. PMC 2474559. PMID 18393943.

External links

• KCNIP1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.