CatSper1

CatSper1, is a protein which in humans is encoded by the CATSPER1 gene.[5][6][7] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.[8]

CATSPER1
Identifiers
Aliases	CATSPER1, CATSPER, SPGF7, CatSper1, cation channel sperm associated 1
External IDs	OMIM: 606389 MGI: 2179947 HomoloGene: 14207 GeneCards: CATSPER1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 66,016,752 bp[1] End 66,026,479 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,335,741 bp[2] End 5,344,280 bp[2]
Gene ontology Molecular function • calcium activated cation channel activity • calcium channel activity • voltage-gated ion channel activity • ion channel activity • GO:0001948 protein binding • high voltage-gated calcium channel activity • voltage-gated calcium channel activity Cellular component • integral component of membrane • CatSper complex • cell projection • membrane • cell membrane • cilium • motile cilium Biological process • cell differentiation • membrane depolarization during action potential • regulation of ion transmembrane transport • ion transport • multicellular organism development • calcium ion transmembrane transport • transmembrane transport • spermatogenesis • sperm-egg recognition • calcium ion transport • flagellated sperm motility • regulation of cilium beat frequency involved in ciliary motility • response to progesterone Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117144	225865
Ensembl	ENSG00000175294	ENSMUSG00000038498
UniProt	Q8NEC5	Q91ZR5
RefSeq (mRNA)	NM_053054	NM_139301
RefSeq (protein)	NP_444282	NP_647462
Location (UCSC)	Chr 11: 66.02 – 66.03 Mb	Chr 19: 5.34 – 5.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000175294 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038498 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.
6. Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE (October 2001). "A sperm ion channel required for sperm motility and male fertility". Nature. 413 (6856): 603–9. doi:10.1038/35098027. PMID 11595941.
7. Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.
8. "CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
9. "Entrez Gene: CatSper1".

Further reading

• Li HG, Liao AH, Ding XF, et al. (2006). "The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa". Asian J. Androl. 8 (3): 301–6. doi:10.1111/j.1745-7262.2006.00132.x. PMID 16625279.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Zhang D, Chen J, Saraf A, et al. (2006). "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity". J. Biol. Chem. 281 (31): 22332–41. doi:10.1074/jbc.M511288200. PMID 16740636.
• Avenarius MR, Hildebrand MS, Zhang Y, et al. (2009). "Human Male Infertility Caused by Mutations in the CATSPER1 Channel Protein". Am. J. Hum. Genet. 84 (4): 505–10. doi:10.1016/j.ajhg.2009.03.004. PMC 2667975. PMID 19344877.
• Garbers DL (2001). "Ion channels. Swimming with sperm". Nature. 413 (6856): 579, 581–2. doi:10.1038/35098164. PMID 11595929.
• Quill TA, Ren D, Clapham DE, Garbers DL (2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.
• Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nikpoor P, Mowla SJ, Movahedin M, et al. (2004). "CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility". Hum. Reprod. 19 (1): 124–8. doi:10.1093/humrep/deh043. PMID 14688170.
• Ren D, Navarro B, Perez G, et al. (2001). "A sperm ion channel required for sperm motility and male fertility". Nature. 413 (6856): 603–9. doi:10.1038/35098027. PMID 11595941.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.