CatSper2

CatSper2, is a protein which in humans is encoded by the CATSPER2 gene.[5][6] CatSper2 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.[7]

CATSPER2
Identifiers
Aliases	CATSPER2, CatSper2, cation channel sperm associated 2
External IDs	OMIM: 607249 MGI: 2387404 HomoloGene: 77423 GeneCards: CATSPER2
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.3 Start 43,628,503 bp[1] End 43,668,118 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 121,392,631 bp[2] End 121,413,792 bp[2]
Gene ontology Molecular function • calcium activated cation channel activity • calcium channel activity • voltage-gated ion channel activity • ion channel activity • GO:0001948 protein binding • voltage-gated sodium channel activity Cellular component • integral component of membrane • CatSper complex • cell projection • membrane • cell membrane • cilium • motile cilium Biological process • cell differentiation • membrane depolarization during action potential • regulation of ion transmembrane transport • ion transport • multicellular organism development • calcium ion transmembrane transport • transmembrane transport • spermatogenesis • sperm-egg recognition • calcium ion transport • neuronal action potential • flagellated sperm motility • sodium ion transmembrane transport • fertilization • sperm capacitation • response to progesterone Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117155	212670
Ensembl	ENSG00000166762	ENSMUSG00000033486
UniProt	Q96P56	A2ARP9
RefSeq (mRNA)	NM_001282309 NM_001282310 NM_054020 NM_172095 NM_172097	NM_153075
RefSeq (protein)	NP_001269238 NP_001269239 NP_742093	n/a
Location (UCSC)	Chr 15: 43.63 – 43.67 Mb	Chr 2: 121.39 – 121.41 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000166762 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033486 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.
6. Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.
7. • "CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
8. "Entrez Gene: CatSper2".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang D, Chen J, Saraf A, et al. (2006). "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity". J. Biol. Chem. 281 (31): 22332–41. doi:10.1074/jbc.M511288200. PMID 16740636.
• Garbers DL (2001). "Ion channels. Swimming with sperm". Nature. 413 (6856): 579, 581–2. doi:10.1038/35098164. PMID 11595929.
• Quill TA, Ren D, Clapham DE, Garbers DL (2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.