KCNS1

Potassium voltage-gated channel subfamily S member 1 is a protein that in humans is encoded by the KCNS1 gene.[5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit.[5][6]

KCNS1
Identifiers
Aliases	KCNS1, KV9.1, potassium voltage-gated channel modifier subfamily S member 1
External IDs	OMIM: 602905 MGI: 1197019 HomoloGene: 20517 GeneCards: KCNS1
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,091,214 bp[1] End 45,101,127 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 164,163,619 bp[2] End 164,171,113 bp[2]
Gene ontology Molecular function • voltage-gated potassium channel activity • ion channel activity • potassium channel regulator activity • potassium channel activity • GO:0001948 protein binding • delayed rectifier potassium channel activity • voltage-gated ion channel activity Cellular component • integral component of membrane • membrane • voltage-gated potassium channel complex • cell membrane • perinuclear region of cytoplasm Biological process • regulation of ion transmembrane transport • protein homooligomerization • ion transport • transmembrane transport • potassium ion transmembrane transport • regulation of delayed rectifier potassium channel activity • potassium ion transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3787	16538
Ensembl	ENSG00000124134	ENSMUSG00000040164
UniProt	Q96KK3	O35173
RefSeq (mRNA)	NM_002251 NM_001322799	NM_008435
RefSeq (protein)	NP_001309728 NP_002242	NP_032461
Location (UCSC)	Chr 20: 45.09 – 45.1 Mb	Chr 2: 164.16 – 164.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000124134 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040164 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M (Oct 1997). "New modulatory alpha subunits for mammalian Shab K+ channels". J Biol Chem. 272 (39): 24371–9. doi:10.1074/jbc.272.39.24371. PMID 9305895.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shepard AR, Rae JL (1999). "Electrically silent potassium channel subunits from human lens epithelium". Am. J. Physiol. 277 (3 Pt 1): C412–24. doi:10.1152/ajpcell.1999.277.3.C412. PMID 10484328.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
• Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.

External links

• Kv9.1+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNS1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)