CLIC2

Chloride intracellular channel protein 2 is a protein that in humans is encoded by the CLIC2 gene.[3][4]

CLIC2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2PER, 2R4V, 2R5G
Identifiers
Aliases	CLIC2, CLIC2b, MRXS32, XAP121, chloride intracellular channel 2, CLCNL2
External IDs	OMIM: 300138 HomoloGene: 48010 GeneCards: CLIC2
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 155,276,211 bp[1] End 155,334,657 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • glutathione transferase activity • voltage-gated ion channel activity • glutathione peroxidase activity • GO:0001948 protein binding • chloride channel activity Cellular component • cytoplasm • integral component of membrane • membrane • intracellular • chloride channel complex • cell nucleus Biological process • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • regulation of ion transmembrane transport • ion transport • negative regulation of ryanodine-sensitive calcium-release channel activity • positive regulation of binding • chloride transport • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • signal transduction • cellular oxidant detoxification • glutathione metabolic process • chloride transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1193	n/a
Ensembl	ENSG00000155962	n/a
UniProt	O15247	n/a
RefSeq (mRNA)	NM_001289	n/a
RefSeq (protein)	NP_001280	n/a
Location (UCSC)	Chr X: 155.28 – 155.33 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti.[4]

See also

• Chloride channel

References

1. GRCh38: Ensembl release 89: ENSG00000155962 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Heiss NS, Poustka A (Nov 1997). "Genomic structure of a novel chloride channel gene, CLIC2, in Xq28". Genomics. 45 (1): 224–8. doi:10.1006/geno.1997.4922. PMID 9339381.
4. "Entrez Gene: CLIC2 chloride intracellular channel 2".

Further reading

• Thiemann A, Gründer S, Pusch M, Jentsch TJ (1992). "A chloride channel widely expressed in epithelial and non-epithelial cells". Nature. 356 (6364): 57–60. doi:10.1038/356057a0. PMID 1311421.
• Rogner UC, Heiss NS, Kioschis P, et al. (1997). "Transcriptional analysis of the candidate region for incontinentia pigmenti (IP2) in Xq28". Genome Res. 6 (10): 922–34. doi:10.1101/gr.6.10.922. PMID 8908511.
• Singh H (2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters. 584 (10): 2112–21. doi:10.1016/j.febslet.2010.03.013. PMID 20226783.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dhani SU, Mohammad-Panah R, Ahmed N, et al. (2003). "Evidence for a functional interaction between the ClC-2 chloride channel and the retrograde motor dynein complex". J. Biol. Chem. 278 (18): 16262–70. doi:10.1074/jbc.M209828200. PMID 12601004.
• Fan L, Yu W, Zhu X (2003). "Interaction of Sedlin with chloride intracellular channel proteins". FEBS Lett. 540 (1–3): 77–80. doi:10.1016/S0014-5793(03)00228-X. PMID 12681486.
• Board PG, Coggan M, Watson S, et al. (2005). "CLIC-2 modulates cardiac ryanodine receptor Ca²⁺ release channels". Int. J. Biochem. Cell Biol. 36 (8): 1599–612. doi:10.1016/j.biocel.2004.01.026. PMID 15147738.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

External links

• CLIC2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CLIC2 genome location and CLIC2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.