CatSper3

CatSper3, is a protein which in humans is encoded by the CATSPER3 gene.[5][6][7][8] CatSper3 is a member of the cation channels of sperm family of proteins. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[9]

CATSPER3
Identifiers
AliasesCATSPER3, CACRC, CatSper3, cation channel sperm associated 3
External IDsOMIM: 609120 MGI: 1924106 HomoloGene: 12658 GeneCards: CATSPER3
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q31.1Start134,967,907 bp[1]
End135,011,696 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

347732

76856

Ensembl

ENSG00000152705

ENSMUSG00000021499

UniProt

Q86XQ3

Q80W99

RefSeq (mRNA)

NM_178019

NM_001252487
NM_001252488
NM_029772

RefSeq (protein)

NP_821138

NP_001239416
NP_001239417
NP_084048

Location (UCSC)Chr 5: 134.97 – 135.01 MbChr 13: 55.78 – 55.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000152705 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021499 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Arias JM, Murbartián J, Perez-Reyes E (March 2003). "Cloning of a novel one-repeat calcium channel-like gene". Biochem. Biophys. Res. Commun. 303 (1): 31–6. doi:10.1016/S0006-291X(03)00276-6. PMID 12646162.
  6. Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). "Identification of human and mouse CatSper3 and CatSper4 genes: Characterisation of a common interaction domain and evidence for expression in testis". Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMC 184451. PMID 12932298.
  7. Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895. PMID 17227845.
  8. Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.


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