CLCC1

Chloride channel CLIC-like 1 also known as CLCC1 is a human gene.[5][6]

CLCC1
Identifiers
Aliases	CLCC1, MCLC, chloride channel CLIC like 1
External IDs	OMIM: 617539 MGI: 2385186 HomoloGene: 9032 GeneCards: CLCC1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 108,929,508 bp[1] End 108,963,457 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F3 Start 108,653,913 bp[2] End 108,678,840 bp[2]
Gene ontology Molecular function • chloride channel activity Cellular component • integral component of membrane • Golgi apparatus • endoplasmic reticulum • membrane • cell nucleus • chloride channel complex • intracellular membrane-bounded organelle Biological process • chloride transport • chloride transmembrane transport • ion transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23155	229725
Ensembl	ENSG00000121940	ENSMUSG00000027884
UniProt	Q96S66	Q99LI2
RefSeq (mRNA)	NM_015127 NM_001048210 NM_001278202 NM_001278203	NM_001177770 NM_001177771 NM_145543 NM_001355632
RefSeq (protein)	NP_001041675 NP_001265131 NP_001265132 NP_055942 NP_001364387 NP_001364388 NP_001364389 NP_001364390 NP_001364391 NP_001364392 NP_001364393 NP_001364394 NP_001364395 NP_001364396 NP_001364397 NP_001364398 NP_001364399	NP_001171241 NP_001171242 NP_663518 NP_001342561
Location (UCSC)	Chr 1: 108.93 – 108.96 Mb	Chr 3: 108.65 – 108.68 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a chloride channel which is related in sequence to the S. cerevisiae MID-1 stretch-activated channel. CLCC1 is located in the membranes of intracellular compartments including endoplasmic reticulum and the Golgi apparatus. It is highly expressed in the testis and moderately in the spleen, liver, kidney, heart, brain, and lung.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000121940 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027884 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
6. Nagasawa M, Kanzaki M, Iino Y, Morishita Y, Kojima I (June 2001). "Identification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus". J. Biol. Chem. 276 (23): 20413–8. doi:10.1074/jbc.M100366200. PMID 11279057.

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Nagasawa M, Kanzaki M, Iino Y, et al. (2001). "Identification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus". J. Biol. Chem. 276 (23): 20413–8. doi:10.1074/jbc.M100366200. PMID 11279057.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

External links

• CLCC1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CLCC1 genome location and CLCC1 gene details page in the UCSC Genome Browser.