GJD4

Gap junction delta-4 protein (GJD4), also known as connexin-40.1 (Cx40.1), is a protein that in humans is encoded by the GJD4 gene.[5]

GJD4
Identifiers
Aliases	GJD4, CX40.1, gap junction protein delta 4
External IDs	OMIM: 611922 MGI: 2444990 HomoloGene: 17692 GeneCards: GJD4
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p11.21 Start 35,605,341 bp[1] End 35,608,935 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 9,278,607 bp[2] End 9,282,809 bp[2]
Orthologs
Species	Human	Mouse
Entrez	219770	225152
Ensembl	ENSG00000177291	ENSMUSG00000036855
UniProt	Q96KN9	Q8BSD4
RefSeq (mRNA)	NM_153368	NM_153086
RefSeq (protein)	NP_699199	NP_694726
Location (UCSC)	Chr 10: 35.61 – 35.61 Mb	Chr 18: 9.28 – 9.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Connexins, such as GJD4, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits.[5][6]

References

1. GRCh38: Ensembl release 89: ENSG00000177291 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036855 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: gap junction protein".
6. Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.