SCN2B

Sodium channel subunit beta-2 is a protein that in humans is encoded by the SCN2B gene.[5][6]

SCN2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FEB, 5FDY
Identifiers
Aliases	SCN2B, ATFB14, sodium voltage-gated channel beta subunit 2
External IDs	OMIM: 601327 MGI: 106921 HomoloGene: 3373 GeneCards: SCN2B
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 118,157,849 bp[1] End 118,176,639 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.2|9 24.84 cM Start 45,117,782 bp[2] End 45,130,070 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • voltage-gated sodium channel activity involved in cardiac muscle cell action potential • sodium channel regulator activity • sodium channel activity • voltage-gated sodium channel activity • voltage-gated ion channel activity Cellular component • integral component of membrane • voltage-gated sodium channel complex • membrane Biological process • chemical synaptic transmission • nervous system development • cardiac muscle cell action potential involved in contraction • sodium ion transport • sodium ion transmembrane transport • regulation of sodium ion transmembrane transporter activity • cardiac muscle contraction • regulation of heart rate by cardiac conduction • regulation of atrial cardiac muscle cell membrane depolarization • membrane depolarization during cardiac muscle cell action potential • regulation of ion transmembrane transport • ion transport • response to pyrethroid Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6327	72821
Ensembl	ENSG00000149575	ENSMUSG00000070304
UniProt	O60939	Q56A07
RefSeq (mRNA)	NM_004588	NM_001014761
RefSeq (protein)	NP_004579	NP_001014761
Location (UCSC)	Chr 11: 118.16 – 118.18 Mb	Chr 9: 45.12 – 45.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Sodium channel

References

1. GRCh38: Ensembl release 89: ENSG00000149575 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070304 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Plummer NW, Meisler MH (May 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics. 57 (2): 323–31. doi:10.1006/geno.1998.5735. PMID 10198179.
6. "Entrez Gene: SCN2B sodium channel, voltage-gated, type II, beta".

Further reading

• Hartshorne RP, Catterall WA (1984). "The sodium channel from rat brain. Purification and subunit composition". J. Biol. Chem. 259 (3): 1667–75. PMID 6319405.
• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Isom LL, Ragsdale DS, De Jongh KS, et al. (1996). "Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif". Cell. 83 (3): 433–42. doi:10.1016/0092-8674(95)90121-3. PMID 8521473.
• Eubanks J, Srinivasan J, Dinulos MB, et al. (1997). "Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel". NeuroReport. 8 (12): 2775–9. doi:10.1097/00001756-199708180-00025. PMID 9295116.
• Bolino A, Seri M, Caroli F, et al. (1999). "Exclusion of the SCN2B gene as candidate for CMT4B". Eur. J. Hum. Genet. 6 (6): 629–34. doi:10.1038/sj.ejhg.5200220. PMID 9887383.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim DY, Ingano LA, Carey BW, et al. (2005). "Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration". J. Biol. Chem. 280 (24): 23251–61. doi:10.1074/jbc.M412938200. PMID 15833746.

External links

• SCN2B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: O60939 (Sodium channel subunit beta-2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.