KCNB2

Potassium voltage-gated channel subfamily B member 2 is a protein that in humans is encoded by the KCNB2 gene.[5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit.[5][6]

KCNB2
Identifiers
Aliases	KCNB2, KV2.2, potassium voltage-gated channel subfamily B member 2
External IDs	OMIM: 607738 MGI: 99632 HomoloGene: 31263 GeneCards: KCNB2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.11 Start 72,537,225 bp[1] End 72,938,349 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 A3|1 4.5 cM Start 15,287,254 bp[2] End 15,723,750 bp[2]
Gene ontology Molecular function • potassium channel activity • delayed rectifier potassium channel activity • voltage-gated ion channel activity • ion channel activity • protein heterodimerization activity • voltage-gated potassium channel activity Cellular component • perikaryon • cell projection • membrane • voltage-gated potassium channel complex • cell membrane • neuronal cell body membrane • dendrite • integral component of membrane • neuronal cell body Biological process • regulation of smooth muscle contraction • regulation of ion transmembrane transport • ion transport • potassium ion transport • transmembrane transport • protein homooligomerization • potassium ion transmembrane transport • protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9312	98741
Ensembl	ENSG00000182674	ENSMUSG00000092083
UniProt	Q92953	A6H8H5
RefSeq (mRNA)	NM_004770	NM_001033195 NM_001098528
RefSeq (protein)	NP_004761	NP_001091998
Location (UCSC)	Chr 8: 72.54 – 72.94 Mb	Chr 1: 15.29 – 15.72 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000182674 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000092083 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schmalz F, Kinsella J, Koh SD, Vogalis F, Schneider A, Flynn ER, Kenyon JL, Horowitz B (Jul 1998). "Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles". Am J Physiol. 274 (5 Pt 1): G901–11. PMID 9612272.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.

Further reading

• Nyholt DR, LaForge KS, Kallela M, et al. (2008). "A high-density association screen of 155 ion transport genes for involvement with common migraine". Hum. Mol. Genet. 17 (21): 3318–31. doi:10.1093/hmg/ddn227. PMC 2566523. PMID 18676988.
• Yan L, Figueroa DJ, Austin CP, et al. (2004). "Expression of voltage-gated potassium channels in human and rhesus pancreatic islets". Diabetes. 53 (3): 597–607. doi:10.2337/diabetes.53.3.597. PMID 14988243.
• Hugnot JP, Salinas M, Lesage F, et al. (1996). "Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels". EMBO J. 15 (13): 3322–31. doi:10.1002/j.1460-2075.1996.tb00697.x. PMC 451895. PMID 8670833.
• Baranzini SE, Wang J, Gibson RA, et al. (2009). "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis". Hum. Mol. Genet. 18 (4): 767–78. doi:10.1093/hmg/ddn388. PMC 4334814. PMID 19010793.
• Vasan RS, Larson MG, Aragam J, et al. (2007). "Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study". BMC Med. Genet. 8 Suppl 1: S2. doi:10.1186/1471-2350-8-S1-S2. PMC 1995617. PMID 17903301.
• Wu C, Ma MH, Brown KR, et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening". Proteomics. 7 (11): 1775–85. doi:10.1002/pmic.200601006. PMID 17474147.
• Salinas M, de Weille J, Guillemare E, et al. (1997). "Modes of regulation of shab K+ channel activity by the Kv8.1 subunit". J. Biol. Chem. 272 (13): 8774–80. doi:10.1074/jbc.272.13.8774. PMID 9079713.

External links

• Kv2.2+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)