KCNH7

Potassium voltage-gated channel subfamily H member 7 is a protein that in humans is encoded by the KCNH7 gene.[5] The protein encoded by this gene is a voltage-gated potassium channel subunit.[5]

KCNH7
Identifiers
Aliases	KCNH7, ERG3, HERG3, Kv11.3, potassium voltage-gated channel subfamily H member 7
External IDs	OMIM: 608169 MGI: 2159566 HomoloGene: 13249 GeneCards: KCNH7
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q24.2 Start 162,371,407 bp[1] End 162,838,767 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.3 Start 62,693,414 bp[2] End 63,184,287 bp[2]
Gene ontology Molecular function • voltage-gated ion channel activity • ion channel activity • voltage-gated potassium channel activity • potassium channel activity Cellular component • cell membrane • membrane • integral component of membrane • integral component of plasma membrane Biological process • ion transport • transmembrane transport • potassium ion transmembrane transport • potassium ion transport • regulation of membrane potential • regulation of ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	90134	170738
Ensembl	ENSG00000184611	ENSMUSG00000059742
UniProt	Q9NS40	Q9ER47
RefSeq (mRNA)	NM_033272 NM_173162	NM_133207
RefSeq (protein)	NP_150375 NP_775185	NP_573470
Location (UCSC)	Chr 2: 162.37 – 162.84 Mb	Chr 2: 62.69 – 63.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000184611 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059742 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.

Further reading

• Akhavan A, Atanasiu R, Noguchi T, et al. (2005). "Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization". J. Cell Sci. 118 (Pt 13): 2803–12. doi:10.1242/jcs.02423. PMID 15961404.
• Ganetzky B, Robertson GA, Wilson GF, et al. (1999). "The eag family of K+ channels in Drosophila and mammals". Ann. N. Y. Acad. Sci. 868: 356–69. doi:10.1111/j.1749-6632.1999.tb11297.x. PMID 10414305.
• Martínez A, Santiago JL, Cénit MC, et al. (2008). "IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk". Eur. J. Hum. Genet. 16 (7): 861–4. doi:10.1038/ejhg.2008.16. PMID 18285833.
• Couturier N, Gourraud PA, Cournu-Rebeix I, et al. (2009). "IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients". Eur. J. Hum. Genet. 17 (6): 844–7. doi:10.1038/ejhg.2008.259. PMC 2947096. PMID 19156166.
• Bauer CK, Wulfsen I, Schäfer R, et al. (2003). "HERG K(+) currents in human prolactin-secreting adenoma cells". Pflügers Arch. 445 (5): 589–600. doi:10.1007/s00424-002-0980-0. PMID 12634931.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wu C, Ma MH, Brown KR, et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening". Proteomics. 7 (11): 1775–85. doi:10.1002/pmic.200601006. PMID 17474147.

External links

• Kv11.3+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNH7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)