KCNG4

Potassium voltage-gated channel subfamily G member 4 is a protein that in humans is encoded by the KCNG4 gene.[5][5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit.[6]

KCNG4
Identifiers
Aliases	KCNG4, KV6.3, KV6.4, potassium voltage-gated channel modifier subfamily G member 4
External IDs	OMIM: 607603 MGI: 1913983 HomoloGene: 23553 GeneCards: KCNG4
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.1 Start 84,218,667 bp[1] End 84,239,750 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 119,623,854 bp[2] End 119,635,680 bp[2]
Gene ontology Molecular function • voltage-gated potassium channel activity • ion channel activity • potassium channel activity • delayed rectifier potassium channel activity • ion channel binding • voltage-gated ion channel activity Cellular component • integral component of membrane • voltage-gated potassium channel complex • cell membrane • membrane Biological process • potassium ion transport • regulation of ion transmembrane transport • protein homooligomerization • ion transport • transmembrane transport • potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	93107	66733
Ensembl	ENSG00000168418	ENSMUSG00000045246
UniProt	Q8TDN1	Q80XM3
RefSeq (mRNA)	NM_172347 NM_133490	NM_025734 NM_001357210
RefSeq (protein)	NP_758857	NP_080010 NP_001344139
Location (UCSC)	Chr 16: 84.22 – 84.24 Mb	Chr 8: 119.62 – 119.64 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000168418 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045246 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ (Jun 2002). "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome". Proc Natl Acad Sci U S A. 99 (12): 7986–91. doi:10.1073/pnas.122617999. PMC 123007. PMID 12060745.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.

Further reading

• Mederos Y, Schnitzler M, Rinné S, Skrobek L, et al. (2009). "Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4". J. Biol. Chem. 284 (7): 4695–704. doi:10.1074/jbc.M808786200. PMID 19074135.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ottschytsch N, Raes AL, Timmermans JP, Snyders DJ (2005). "Domain analysis of Kv6.3, an electrically silent channel". J. Physiol. 568 (Pt 3): 737–47. doi:10.1113/jphysiol.2005.090142. PMC 1464172. PMID 16096342.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• Kv6.4+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNG4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)