AQP5

Aquaporin-5 is a protein that in humans is encoded by the AQP5 gene.[5][6]

AQP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3D9S, 5C5X, 5DYE
Identifiers
Aliases	AQP5, AQP-5, PPKB, aquaporin 5
External IDs	OMIM: 600442 MGI: 106215 HomoloGene: 20398 GeneCards: AQP5
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 49,961,872 bp[1] End 49,965,682 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F1|15 56.13 cM Start 99,590,782 bp[2] End 99,594,829 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transporter activity • GO:0001948 protein binding • water channel activity • identical protein binding • channel activity Cellular component • integral component of membrane • membrane • cell membrane • integral component of plasma membrane • microvilli • basal plasma membrane • apical plasma membrane • endoplasmic reticulum • extracellular exosome • cytoplasmic vesicle membrane • cytoplasmic vesicle Biological process • excretion • water transport • pancreatic juice secretion • salivation • odontogenesis • ion transmembrane transport • camera-type eye morphogenesis • carbon dioxide transport • transport • transmembrane transport • protein homotetramerization • cellular hypotonic response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	362	11830
Ensembl	ENSG00000161798	ENSMUSG00000044217
UniProt	P55064	Q9WTY4
RefSeq (mRNA)	NM_001651	NM_009701
RefSeq (protein)	NP_001642	NP_033831
Location (UCSC)	Chr 12: 49.96 – 49.97 Mb	Chr 15: 99.59 – 99.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions [6]. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.[6]

See also

• Aquaporin

References

1. GRCh38: Ensembl release 89: ENSG00000161798 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044217 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee MD, Bhakta KY, Raina S, Yonescu R, Griffin CA, Copeland NG, Gilbert DJ, Jenkins NA, Preston GM, Agre P (Jun 1996). "The human Aquaporin-5 gene. Molecular characterization and chromosomal localization". J Biol Chem. 271 (15): 8599–604. doi:10.1074/jbc.271.15.8599. PMID 8621489.
6. "Entrez Gene: AQP5 aquaporin 5".

Further reading

• Verkman AS (2003). "Role of aquaporin water channels in eye function". Exp. Eye Res. 76 (2): 137–43. doi:10.1016/S0014-4835(02)00303-2. PMID 12565800.
• Ma T, Yang B, Umenishi F, Verkman AS (1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13". Genomics. 43 (3): 387–9. doi:10.1006/geno.1997.4836. PMID 9268644.
• Smith JK, Siddiqui AA, Modica LA, et al. (1999). "Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands". J. Interferon Cytokine Res. 19 (8): 929–35. doi:10.1089/107999099313479. PMID 10476940.
• Kreda SM, Gynn MC, Fenstermacher DA, et al. (2001). "Expression and localization of epithelial aquaporins in the adult human lung". Am. J. Respir. Cell Mol. Biol. 24 (3): 224–34. doi:10.1165/ajrcmb.24.3.4367. PMID 11245621.
• Gresz V, Kwon TH, Hurley PT, et al. (2001). "Identification and localization of aquaporin water channels in human salivary glands". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G247–54. PMID 11408278.
• Nejsum LN, Kwon TH, Jensen UB, et al. (2002). "Functional requirement of aquaporin-5 in plasma membranes of sweat glands". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 511–6. doi:10.1073/pnas.012588099. PMC 117591. PMID 11773623.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Burghardt B, Elkaer ML, Kwon TH, et al. (2003). "Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas". Gut. 52 (7): 1008–16. doi:10.1136/gut.52.7.1008. PMC 1773699. PMID 12801959.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Chen Z, Wang X, Gao L, et al. (2006). "Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells". Biochem. Biophys. Res. Commun. 342 (3): 775–81. doi:10.1016/j.bbrc.2006.01.103. PMID 16500622.
• Sidhaye VK, Güler AD, Schweitzer KS, et al. (2006). "Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions". Proc. Natl. Acad. Sci. U.S.A. 103 (12): 4747–52. doi:10.1073/pnas.0511211103. PMC 1450241. PMID 16537379.
• Pedersen PS, Braunstein TH, Jørgensen A, et al. (2007). "Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress". Pflügers Arch. 453 (6): 777–85. doi:10.1007/s00424-006-0157-3. PMID 17043812.
• Skowron-zwarg M, Boland S, Caruso N, et al. (2007). "Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation". Exp. Cell Res. 313 (12): 2695–702. doi:10.1016/j.yexcr.2007.02.035. PMID 17553491.

External links

• AQP5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human AQP5 genome location and AQP5 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.