CLCN6

Chloride transport protein 6 is a protein that in humans is encoded by the CLCN6 gene.[5][6]

CLCN6
Identifiers
Aliases	CLCN6, CLC-6, chloride voltage-gated channel 6
External IDs	OMIM: 602726 MGI: 1347049 HomoloGene: 985 GeneCards: CLCN6
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 11,806,096 bp[1] End 11,848,079 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 78.67 cM Start 148,004,259 bp[2] End 148,038,821 bp[2]
Gene ontology Molecular function • nucleotide binding • ion channel activity • ATP binding • antiporter activity • voltage-gated chloride channel activity • GO:0001948 protein binding • chloride transmembrane transporter activity • GO:0022891 transmembrane transporter activity Cellular component • integral component of membrane • lysosomal membrane • endosome • endosome membrane • membrane • intracellular membrane-bounded organelle Biological process • cell volume homeostasis • response to mechanical stimulus • chloride transport • ion transmembrane transport • ion transport • signal transduction • regulation of anion transmembrane transport • transmembrane transport • chloride transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1185	26372
Ensembl	ENSG00000011021	ENSMUSG00000029016
UniProt	P51797	O35454
RefSeq (mRNA)	NM_001256959 NM_001286 NM_021735 NM_021736 NM_021737	NM_011929
RefSeq (protein)	NP_001243888 NP_001277	NP_036059
Location (UCSC)	Chr 1: 11.81 – 11.85 Mb	Chr 4: 148 – 148.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.[6]

See also

• Chloride channel

References

1. GRCh38: Ensembl release 89: ENSG00000011021 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029016 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brandt S, Jentsch TJ (Feb 1996). "ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family". FEBS Lett. 377 (1): 15–20. doi:10.1016/0014-5793(95)01298-2. PMID 8543009.
6. "Entrez Gene: CLCN6 chloride channel 6".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
• Eggermont J, Buyse G, Voets T, et al. (1997). "Alternative splicing of ClC-6 (a member of the CIC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific". Biochem. J. 325 (Pt 1): 269–76. doi:10.1042/bj3250269. PMC 1218554. PMID 9224655.
• Eggermont J (1998). "The exon-intron architecture of human chloride channel genes is not conserved". Biochim. Biophys. Acta. 1397 (2): 156–60. doi:10.1016/s0167-4781(98)00014-1. PMID 9565675.
• Lamb FS, Clayton GH, Liu BX, et al. (1999). "Expression of CLCN voltage-gated chloride channel genes in human blood vessels". J. Mol. Cell. Cardiol. 31 (3): 657–66. doi:10.1006/jmcc.1998.0901. PMID 10198195.
• Kornak U, Bösl MR, Kubisch C (1999). "Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes(1)". Biochim. Biophys. Acta. 1447 (1): 100–6. doi:10.1016/s0167-4781(99)00128-1. PMID 10500249.
• Lamb FS, Graeff RW, Clayton GH, et al. (2001). "Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium". Am. J. Respir. Cell Mol. Biol. 24 (4): 376–81. doi:10.1165/ajrcmb.24.4.4114. PMID 11306429.
• Tran P, Leclerc D, Chan M, et al. (2003). "Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms". Mamm. Genome. 13 (9): 483–92. doi:10.1007/s00335-002-2167-6. PMID 12370778.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

External links

• CLCN6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CLCN6 genome location and CLCN6 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.