KCNAB1

Voltage-gated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNAB1 gene.[5][6][7]

KCNAB1
Identifiers
Aliases	KCNAB1, AKR6A3, KCNA1B, KV-BETA-1, Kvb1.3, hKvBeta3, hKvb3, potassium voltage-gated channel subfamily A member regulatory beta subunit 1
External IDs	OMIM: 601141 MGI: 109155 HomoloGene: 56491 GeneCards: KCNAB1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.31 Start 156,037,701 bp[1] End 156,539,138 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 E1|3 30.15 cM Start 64,949,196 bp[2] End 65,378,223 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • aldo-keto reductase (NADP) activity • voltage-gated ion channel activity • potassium channel regulator activity • NADPH binding • voltage-gated potassium channel activity • oxidoreductase activity • protein domain specific binding • ion channel binding Cellular component • cytoplasm • integral component of membrane • cytosol • perikaryon • membrane • extrinsic component of cytoplasmic side of plasma membrane • cell membrane • axon • neuronal cell body • proximal dendrite • potassium channel complex • dendrite cytoplasm • juxtaparanode region of axon • voltage-gated potassium channel complex Biological process • diaphragm development • regulation of ion transmembrane transport • ion transport • potassium ion transport • heart development • brain development • regulation of delayed rectifier potassium channel activity • transmembrane transport • regulation of potassium ion transmembrane transporter activity • potassium ion transmembrane transport • learning or memory • myoblast differentiation • oxidation-reduction process • skeletal muscle tissue development • regulation of potassium ion transmembrane transport • negative regulation of delayed rectifier potassium channel activity • negative regulation of voltage-gated potassium channel activity • ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7881	16497
Ensembl	ENSG00000169282	ENSMUSG00000027827
UniProt	Q14722 Q5MJQ3	P63143
RefSeq (mRNA)	NM_001308217 NM_001308222 NM_003471 NM_172159 NM_172160	NM_001289450 NM_010597 NM_001357358
RefSeq (protein)	NP_001295146 NP_001295151 NP_003462 NP_751891 NP_751892 NP_001295151.1	NP_001276379 NP_034727 NP_001344287
Location (UCSC)	Chr 3: 156.04 – 156.54 Mb	Chr 3: 64.95 – 65.38 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms that are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.[7]

See also

• Voltage-gated potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000169282 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027827 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schultz D, Litt M, Smith L, Thayer M, McCormack K (Mar 1997). "Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B". Genomics. 31 (3): 389–91. doi:10.1006/geno.1996.0065. PMID 8838324.
6. England SK, Uebele VN, Kodali J, Bennett PB, Tamkun MM (Jan 1996). "A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing". J Biol Chem. 270 (48): 28531–4. doi:10.1074/jbc.270.48.28531. PMID 7499366.
7. "Entrez Gene: KCNAB1 potassium voltage-gated channel, shaker-related subfamily, beta member 1".

Further reading

• England SK, Uebele VN, Shear H, et al. (1995). "Characterization of a voltage-gated K+ channel beta subunit expressed in human heart". Proc. Natl. Acad. Sci. U.S.A. 92 (14): 6309–13. doi:10.1073/pnas.92.14.6309. PMC 41507. PMID 7603988.
• McCormack K, McCormack T, Tanouye M, et al. (1995). "Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product". FEBS Lett. 370 (1–2): 32–6. doi:10.1016/0014-5793(95)00785-8. PMID 7649300.
• Majumder K, De Biasi M, Wang Z, Wible BA (1995). "Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium". FEBS Lett. 361 (1): 13–6. doi:10.1016/0014-5793(95)00120-X. PMID 7890032.
• Morales MJ, Castellino RC, Crews AL, et al. (1995). "A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits". J. Biol. Chem. 270 (11): 6272–7. doi:10.1074/jbc.270.11.6272. PMID 7890764.
• McCormack T, McCormack K (1995). "Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily". Cell. 79 (7): 1133–5. doi:10.1016/0092-8674(94)90004-3. PMID 8001150.
• Nakahira K, Shi G, Rhodes KJ, Trimmer JS (1996). "Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits". J. Biol. Chem. 271 (12): 7084–9. doi:10.1074/jbc.271.12.7084. PMID 8636142.
• Leicher T, Roeper J, Weber K, et al. (1997). "Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B)". Neuropharmacology. 35 (7): 787–95. doi:10.1016/0028-3908(96)00133-5. PMID 8938711.
• Hanada T, Lin L, Chandy KG, et al. (1997). "Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes". J. Biol. Chem. 272 (43): 26899–904. doi:10.1074/jbc.272.43.26899. PMID 9341123.
• Leicher T, Bähring R, Isbrandt D, Pongs O (1999). "Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel". J. Biol. Chem. 273 (52): 35095–101. doi:10.1074/jbc.273.52.35095. PMID 9857044.
• Suzuki Y, Ishihara D, Sasaki M, et al. (2000). "Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries". Genomics. 64 (3): 286–97. doi:10.1006/geno.2000.6076. PMID 10756096.
• Kuryshev YA, Wible BA, Gudz TI, et al. (2001). "KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression". Am. J. Physiol., Cell Physiol. 281 (1): C290–9. doi:10.1152/ajpcell.2001.281.1.c290. PMID 11401852.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nie DY, Zhou ZH, Ang BT, et al. (2003). "Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K+ channel localization". EMBO J. 22 (21): 5666–78. doi:10.1093/emboj/cdg570. PMC 275427. PMID 14592966.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• KCNAB1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.