KCNK1

Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.[5][6][7]

KCNK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKCNK1, DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1, potassium two pore domain channel subfamily K member 1
External IDsOMIM: 601745 MGI: 109322 HomoloGene: 1691 GeneCards: KCNK1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q42.2Start233,614,106 bp[1]
End233,672,514 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

3775

16525

Ensembl

ENSG00000135750

ENSMUSG00000033998

UniProt

O00180

O08581

RefSeq (mRNA)

NM_002245

NM_008430

RefSeq (protein)

NP_002236

NP_032456

Location (UCSC)Chr 1: 233.61 – 233.67 MbChr 8: 126 – 126.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes K2P1.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, and it may require other non-pore-forming proteins for activity.[7]

See also

  • Tandem pore domain potassium channel

References

  1. GRCh38: Ensembl release 89: ENSG00000135750 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033998 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lesage F, Mattei M, Fink M, Barhanin J, Lazdunski M (Dec 1996). "Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43". Genomics. 34 (1): 153–5. doi:10.1006/geno.1996.0259. PMID 8661042.
  6. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
  7. "Entrez Gene: KCNK1 potassium channel, subfamily K, member 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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