CLIC6

Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene.[5][6]

CLIC6
Identifiers
Aliases	CLIC6, CLIC1L, chloride intracellular channel 6
External IDs	OMIM: 615321 MGI: 2146607 HomoloGene: 43154 GeneCards: CLIC6
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.12 Start 34,669,389 bp[1] End 34,718,227 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C4 Start 92,485,736 bp[2] End 92,541,243 bp[2]
Gene ontology Molecular function • voltage-gated ion channel activity • glutathione transferase activity • chloride channel activity • D2 dopamine receptor binding • D3 dopamine receptor binding • D4 dopamine receptor binding Cellular component • integral component of membrane • cell membrane • extracellular exosome • membrane • chloride channel complex • cell nucleus • cytoplasm Biological process • regulation of ion transmembrane transport • chloride transport • ion transport • glutathione metabolic process • chloride transmembrane transport • transport • ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54102	209195
Ensembl	ENSG00000159212	ENSMUSG00000022949
UniProt	Q96NY7	Q8BHB9
RefSeq (mRNA)	NM_053277 NM_001317009	NM_172469
RefSeq (protein)	NP_001303938 NP_444507	NP_766057
Location (UCSC)	Chr 21: 34.67 – 34.72 Mb	Chr 16: 92.49 – 92.54 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The CLIC6 gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.[6]

Interactions

CLIC6 has been shown to interact with Dopamine receptor D3.[7]

See also

• Chloride channel

References

1. GRCh38: Ensembl release 89: ENSG00000159212 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022949 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (Jun 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
6. "Entrez Gene: CLIC6 chloride intracellular channel 6".
7. Griffon, Nathalie; Jeanneteau Freddy; Prieur Fanny; Diaz Jorge; Sokoloff Pierre (Sep 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Res. Mol. Brain Res. Netherlands. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. ISSN 0169-328X. PMID 14499480.

Further reading

• Singh H (2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters. 584 (10): 2112–21. doi:10.1016/j.febslet.2010.03.013. PMID 20226783.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Strippoli P, D'Addabbo P, Lenzi L, et al. (2003). "Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q". Mamm. Genome. 13 (8): 456–62. doi:10.1007/s00335-001-2157-0. PMID 12226712.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4. PMID 12747765.
• Griffon N, Jeanneteau F, Prieur F, et al. (2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Res. Mol. Brain Res. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.
• Friedli M, Guipponi M, Bertrand S, et al. (2004). "Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12". Gene. 320: 31–40. doi:10.1016/S0378-1119(03)00830-8. PMID 14597386.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• CLIC6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CLIC6 genome location and CLIC6 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.