KCNK12

Potassium channel, subfamily K, member 12, also known as KCNK12 is a human gene. The protein encoded by this gene, K_2P12.1, is a potassium channel containing two pore-forming P domains.[5]

KCNK12
Identifiers
Aliases	KCNK12, K2p12.1, THIK-2, THIK2, potassium two pore domain channel subfamily K member 12
External IDs	OMIM: 607366 MGI: 2684043 HomoloGene: 11107 GeneCards: KCNK12
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p16.3 Start 47,509,290 bp[1] End 47,570,985 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E4 Start 87,745,801 bp[2] End 87,797,994 bp[2]
Gene ontology Molecular function • potassium channel activity • voltage-gated ion channel activity • potassium ion leak channel activity Cellular component • integral component of membrane • membrane • integral component of plasma membrane Biological process • potassium ion transport • regulation of ion transmembrane transport • ion transport • stabilization of membrane potential • potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56660	210741
Ensembl	ENSG00000184261	ENSMUSG00000050138
UniProt	Q9HB15	Q76M80
RefSeq (mRNA)	NM_022055	NM_199251
RefSeq (protein)	NP_071338	NP_954859
Location (UCSC)	Chr 2: 47.51 – 47.57 Mb	Chr 17: 87.75 – 87.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tandem pore domain potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000184261 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050138 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C (March 2001). "THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels". J. Biol. Chem. 276 (10): 7302–11. doi:10.1074/jbc.M008985200. PMID 11060316.

Further reading

• Girard C, Duprat F, Terrenoire C, et al. (2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem. Biophys. Res. Commun. 282 (1): 249–56. doi:10.1006/bbrc.2001.4562. PMID 11263999.
• Nyholt DR, LaForge KS, Kallela M, et al. (2008). "A high-density association screen of 155 ion transport genes for involvement with common migraine". Hum. Mol. Genet. 17 (21): 3318–31. doi:10.1093/hmg/ddn227. PMC 2566523. PMID 18676988.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Theilig F, Goranova I, Hirsch JR, et al. (2008). "Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney". Cell. Physiol. Biochem. 21 (1–3): 63–74. doi:10.1159/000113748. PMID 18209473.

External links

• KCNK12+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)