KCNU1

Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the K_Ca5.1 protein.[5]

KCNU1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HPF
Identifiers
Aliases	KCNU1, KCNMC1, KCa5, KCa5.1, Kcnma3, Slo3, potassium calcium-activated channel subfamily U member 1
External IDs	OMIM: 615215 MGI: 1202300 HomoloGene: 7392 GeneCards: KCNU1
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.23 Start 36,784,324 bp[1] End 36,936,125 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 25,849,623 bp[2] End 25,937,939 bp[2]
Gene ontology Molecular function • voltage-gated potassium channel activity • large conductance calcium-activated potassium channel activity • ion channel activity • potassium channel activity • voltage-gated ion channel activity • calcium-activated potassium channel activity • outward rectifier potassium channel activity Cellular component • integral component of membrane • voltage-gated potassium channel complex • cell membrane • membrane Biological process • potassium ion transport • regulation of ion transmembrane transport • ion transport • transmembrane transport • potassium ion transmembrane transport • sperm-egg recognition • reproductive process • regulation of membrane potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	157855	16532
Ensembl	ENSG00000215262	ENSMUSG00000031576
UniProt	A8MYU2	O54982
RefSeq (mRNA)	NM_001031836	NM_008432
RefSeq (protein)	NP_001027006	NP_032458
Location (UCSC)	Chr 8: 36.78 – 36.94 Mb	Chr 8: 25.85 – 25.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Although this channel is structurally related to the calcium-activated potassium channels, it cannot be classified as such since it is activated by high intracellular pH and relatively insensitive to changes in calcium concentrations.[6][7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000215262 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031576 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (February 1998). "Slo3, a novel pH-sensitive K⁺ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.
6. Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103.
7. Zhang X, Zeng X, Xia XM, Lingle CJ (September 2006). "pH-regulated Slo3 K⁺ channels: properties of unitary currents". J. Gen. Physiol. 128 (3): 301–15. doi:10.1085/jgp.200609551. PMC 2151565. PMID 16940554.
8. Zhang X, Zeng X, Lingle CJ (September 2006). "Slo3 K⁺ channels: voltage and pH dependence of macroscopic currents". J. Gen. Physiol. 128 (3): 317–36. doi:10.1085/jgp.200609552. PMC 2151566. PMID 16940555.

Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).

External links

• Overview of all the structural information available in the PDB for UniProt: A8MYU2 (Potassium channel subfamily U member 1) at the PDBe-KB.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Schreiber M, Wei A, Yuan A, et al. (1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.
• Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature. 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.
• Wei AD, Gutman GA, Aldrich R, et al. (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103.

Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).