KCNA7

Potassium voltage-gated channel subfamily A member 7 also known as Kv1.7 is a protein that in humans is encoded by the KCNA7 gene.[4][4] The protein encoded by this gene is a voltage-gated potassium channel subunit. It may contribute to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.[5]

KCNA7
Identifiers
AliasesKCNA7, HAK6, KV1.7, potassium voltage-gated channel subfamily A member 7
External IDsOMIM: 176268 MGI: 96664 HomoloGene: 7791 GeneCards: KCNA7
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.33Start49,067,418 bp[1]
End49,072,941 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

3743

16495

Ensembl

ENSG00000104848

n/a

UniProt

Q96RP8

Q17ST2

RefSeq (mRNA)

NM_031886

NM_010596

RefSeq (protein)

NP_114092

NP_034726

Location (UCSC)Chr 19: 49.07 – 49.07 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000104848 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
  5. Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". J. Mol. Cell. Cardiol. 33 (5): 851–72. doi:10.1006/jmcc.2001.1376. PMID 11343410.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.