KCNA10

Potassium voltage-gated channel subfamily A member 10 also known as K_v1.8 is a protein that in humans is encoded by the KCNA10 gene.[5][5] The protein encoded by this gene is a voltage-gated potassium channel subunit.

KCNA10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AFL
Identifiers
Aliases	KCNA10, Kcn1, Kv1.8, potassium voltage-gated channel subfamily A member 10
External IDs	OMIM: 602420 MGI: 3037820 HomoloGene: 4054 GeneCards: KCNA10
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 110,517,217 bp[1] End 110,519,175 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.3|3 46.64 cM Start 107,183,056 bp[2] End 107,195,721 bp[2]
Gene ontology Molecular function • intracellular cyclic nucleotide activated cation channel activity • voltage-gated ion channel activity • ion channel activity • potassium channel activity • voltage-gated potassium channel activity • delayed rectifier potassium channel activity • outward rectifier potassium channel activity Cellular component • cell membrane • membrane • voltage-gated potassium channel complex • integral component of membrane Biological process • ion transport • transmembrane transport • potassium ion transport • protein homooligomerization • regulation of ion transmembrane transport • potassium ion transmembrane transport • potassium ion export across plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3744	242151
Ensembl	ENSG00000143105	ENSMUSG00000042861
UniProt	Q16322	B2RQA1
RefSeq (mRNA)	NM_005549	NM_001081140
RefSeq (protein)	NP_005540	NP_001074609
Location (UCSC)	Chr 1: 110.52 – 110.52 Mb	Chr 3: 107.18 – 107.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000143105 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042861 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.

Further reading

• Landes GM, Curran ME, Keating MT (1995). "Molecular characterization and refined genomic localization of three human potassium ion channel genes". Cytogenet. Cell Genet. 70 (3–4): 280–4. doi:10.1159/000134052. PMID 7789190.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tian S, Liu W, Wu Y, et al. (2002). "Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit". Am. J. Physiol. Renal Physiol. 283 (1): F142–9. doi:10.1152/ajprenal.00258.2001. PMID 12060596.
• Orias M, Bray-Ward P, Curran ME, et al. (1997). "Genomic localization of the human gene for KCNA10, a cGMP-activated K channel". Genomics. 42 (1): 33–7. doi:10.1006/geno.1997.4712. PMID 9177773.
• Lang R, Lee G, Liu W, et al. (2000). "KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels". Am. J. Physiol. Renal Physiol. 278 (6): F1013–21. doi:10.1152/ajprenal.2000.278.6.F1013. PMID 10836990.
• Yao X, Tian S, Chan HY, et al. (2002). "Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule". J. Am. Soc. Nephrol. 13 (12): 2831–9. doi:10.1097/01.ASN.0000036866.37886.C5. PMID 12444201.

External links

• Kv1.8+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNA10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)