KCNG3

Potassium voltage-gated channel subfamily G member 3 is a protein that in humans is encoded by the KCNG3 gene.[5][5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit.[6]

KCNG3
Identifiers
Aliases	KCNG3, KV10.1, KV6.3, potassium voltage-gated channel modifier subfamily G member 3
External IDs	OMIM: 606767 MGI: 2663923 HomoloGene: 15168 GeneCards: KCNG3
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p21 Start 42,442,017 bp[1] End 42,493,982 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E4 Start 83,585,957 bp[2] End 83,631,895 bp[2]
Gene ontology Molecular function • voltage-gated potassium channel activity • ion channel activity • potassium channel activity • GO:0001948 protein binding • delayed rectifier potassium channel activity • voltage-gated ion channel activity Cellular component • cytoplasm • integral component of membrane • voltage-gated potassium channel complex • cell membrane • endoplasmic reticulum • membrane Biological process • potassium ion transport • regulation of ion transmembrane transport • protein homooligomerization • ion transport • transmembrane transport • potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	170850	225030
Ensembl	ENSG00000171126	ENSMUSG00000045053
UniProt	Q8TAE7	P59053
RefSeq (mRNA)	NM_172344 NM_133329	NM_153512
RefSeq (protein)	NP_579875 NP_758847	NP_705732
Location (UCSC)	Chr 2: 42.44 – 42.49 Mb	Chr 17: 83.59 – 83.63 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000171126 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045053 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sano Y, Mochizuki S, Miyake A, Kitada C, Inamura K, Yokoi H, Nozawa K, Matsushime H, Furuichi K (Feb 2002). "Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1". FEBS Lett. 512 (1–3): 230–4. doi:10.1016/S0014-5793(02)02267-6. PMID 11852086.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.

Further reading

• Mederos Y, Schnitzler M, Rinné S, Skrobek L, et al. (2009). "Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4". J. Biol. Chem. 284 (7): 4695–704. doi:10.1074/jbc.M808786200. PMID 19074135.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ (2002). "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7986–91. doi:10.1073/pnas.122617999. PMC 123007. PMID 12060745.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Vega-Saenz de Miera EC (2004). "Modification of Kv2.1 K+ currents by the silent Kv10 subunits". Brain Res. Mol. Brain Res. 123 (1–2): 91–103. doi:10.1016/j.molbrainres.2004.01.004. PMID 15046870.

External links

• Kv6.3+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNG3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)