AQP8

Aquaporin-8 is a protein that in humans is encoded by the AQP8 gene.[5][6][7]

AQP8
Identifiers
Aliases	AQP8, AQP-8, aquaporin 8
External IDs	OMIM: 603750 MGI: 1195271 HomoloGene: 68166 GeneCards: AQP8
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.1 Start 25,215,731 bp[1] End 25,228,932 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 67.42 cM|7 F3 Start 123,462,291 bp[2] End 123,468,004 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • water channel activity • channel activity Cellular component • integral component of membrane • cell membrane • apical part of cell • integral component of plasma membrane • membrane • mitochondrion • mitochondrial membranes Biological process • ion transmembrane transport • cellular response to cAMP • water transport • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	343	11833
Ensembl	ENSG00000103375	ENSMUSG00000030762
UniProt	O94778	P56404
RefSeq (mRNA)	NM_001169	NM_001109045 NM_007474
RefSeq (protein)	NP_001160	NP_001102515 NP_031500
Location (UCSC)	Chr 16: 25.22 – 25.23 Mb	Chr 7: 123.46 – 123.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues.[7]

See also

• Aquaporin

References

1. GRCh38: Ensembl release 89: ENSG00000103375 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030762 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Koyama N, Ishibashi K, Kuwahara M, Inase N, Ichioka M, Sasaki S, Marumo F (Jan 1999). "Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene". Genomics. 54 (1): 169–72. doi:10.1006/geno.1998.5552. PMID 9806845.
6. Viggiano L, Rocchi M, Svelto M, Calamita G (Jul 1999). "Assignment of the aquaporin-8 water channel gene (AQP8) to human chromosome 16p12". Cytogenet Cell Genet. 84 (3–4): 208–10. doi:10.1159/000015260. PMID 10393433.
7. "Entrez Gene: AQP8 aquaporin 8".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Harrington DJ, Adachi K, Royer WE (1997). "The high resolution crystal structure of deoxyhemoglobin S". J. Mol. Biol. 272 (3): 398–407. doi:10.1006/jmbi.1997.1253. PMID 9325099.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Fischer H, Stenling R, Rubio C, Lindblom A (2003). "Differential expression of Aquaporin 8 in human colonic epithelial cells and colorectal tumors". BMC Physiol. 1: 1. doi:10.1186/1472-6793-1-1. PMC 32180. PMID 11231887.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
• Wang S, Kallichanda N, Song W, et al. (2001). "Expression of aquaporin-8 in human placenta and chorioamniotic membranes: evidence of molecular mechanism for intramembranous amniotic fluid resorption". Am. J. Obstet. Gynecol. 185 (5): 1226–31. doi:10.1067/mob.[phone]. PMID 11717661.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang S, Chen J, Au KT, Ross MG (2003). "Expression of aquaporin 8 and its up-regulation by cyclic adenosine monophosphate in human WISH cells". Am. J. Obstet. Gynecol. 188 (4): 997–1001. doi:10.1067/mob.[phone]. PMID 12712100.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zahn A, Moehle C, Langmann T, et al. (2007). "Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis". World J. Gastroenterol. 13 (11): 1687–95. PMID 17461471.

External links

• AQP8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human AQP8 genome location and AQP8 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.