GJA10

Gap junction alpha-10 protein, also known as connexin-62 (Cx62), is a protein that in humans is encoded by the GJA10 gene.[4]

GJA10
Identifiers
Aliases	GJA10, CX62, gap junction protein alpha 10
External IDs	OMIM: 611924 MGI: 1339969 HomoloGene: 7733 GeneCards: GJA10
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q15 Start 89,894,469 bp[1] End 89,921,760 bp[1]
Gene ontology Molecular function • gap junction channel activity Cellular component • integral component of membrane • gap junction • cell junction • cell membrane • connexon • membrane Biological process • synapse assembly • cell communication • gamete generation • transmembrane transport • response to light stimulus • detection of light stimulus involved in visual perception Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84694	14610
Ensembl	ENSG00000135355 ENSG00000288435	n/a
UniProt	Q969M2	Q9WUS4
RefSeq (mRNA)	NM_032602	NM_010289
RefSeq (protein)	NP_115991	NP_034419
Location (UCSC)	Chr 6: 89.89 – 89.92 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Connexins, such as GJA10, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits.[4][5]

References

1. ENSG00000288435 GRCh38: Ensembl release 89: ENSG00000135355, ENSG00000288435 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: gap junction protein".
5. Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038.

Further reading

• Hosgood HD, Zhang L, Shen M, et al. (2009). "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity". Occup Environ Med. 66 (12): 848–53. doi:10.1136/oem.2008.044024. PMC 2928224. PMID 19773279.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.