KCNK13

Potassium channel, subfamily K, member 13, also known as KCNK13 is a human gene. The protein encoded by this gene, K_2P13.1 is a potassium channel containing two pore-forming P domains.[5][6]

KCNK13
Identifiers
Aliases	KCNK13, K2p13.1, THIK-1, THIK1, potassium two pore domain channel subfamily K member 13
External IDs	OMIM: 607367 MGI: 2384976 HomoloGene: 69351 GeneCards: KCNK13
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.11 Start 90,061,994 bp[1] End 90,185,853 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 99,964,499 bp[2] End 100,062,682 bp[2]
Gene ontology Molecular function • potassium channel activity • voltage-gated ion channel activity • potassium ion leak channel activity Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane Biological process • potassium ion transport • regulation of ion transmembrane transport • ion transport • stabilization of membrane potential • potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56659	217826
Ensembl	ENSG00000152315	ENSMUSG00000045404
UniProt	Q9HB14	Q8R1P5
RefSeq (mRNA)	NM_022054	NM_001164426 NM_001164427 NM_146037
RefSeq (protein)	NP_071337	NP_001157898 NP_001157899 NP_666149
Location (UCSC)	Chr 14: 90.06 – 90.19 Mb	Chr 12: 99.96 – 100.06 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tandem pore domain potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000152315 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045404 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C (March 2001). "THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels". J. Biol. Chem. 276 (10): 7302–11. doi:10.1074/jbc.M008985200. PMID 11060316.
6. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fearon IM, Campanucci VA, Brown ST, et al. (2006). "Acute hypoxic regulation of recombinant THIK-1 stably expressed in HEK293 cells". Adv. Exp. Med. Biol. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 580: 203–8, discussion 351–9. doi:10.1007/0-387-31311-7_31. ISBN 978-0-387-31310-8. PMID 16683720.
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Theilig F, Goranova I, Hirsch JR, et al. (2008). "Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney". Cell. Physiol. Biochem. 21 (1–3): 63–74. doi:10.1159/000113748. PMID 18209473.
• Gierten J, Ficker E, Bloehs R, et al. (2008). "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein". Br. J. Pharmacol. 154 (8): 1680–90. doi:10.1038/bjp.2008.213. PMC 2518462. PMID 18516069.

External links

• KCNK13+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)