KDM3B

Lysine-specific demethylase 3B is an enzyme that in humans is encoded by the KDM3B gene.[4][5] KDM3B belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

KDM3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C8D
Identifiers
Aliases	KDM3B, 5qNCA, C5orf7, JMJD1B, NET22, lysine demethylase 3B, DIJOS
External IDs	OMIM: 609373 MGI: 1923356 HomoloGene: 41145 GeneCards: KDM3B
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.2 Start 138,352,685 bp[1] End 138,437,028 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • oxidoreductase activity • antioxidant activity • dioxygenase activity • metal ion binding • histone demethylase activity • transcription regulatory region sequence-specific DNA binding • chromatin DNA binding • histone demethylase activity (H3-K9 specific) Cellular component • chromatin • cell nucleus • nucleoplasm Biological process • cellular oxidant detoxification • response to cisplatin • oxidation-reduction process • transcription, DNA-templated • regulation of transcription, DNA-templated • histone H3-K9 demethylation • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51780	277250
Ensembl	ENSG00000120733	n/a
UniProt	Q7LBC6	Q6ZPY7
RefSeq (mRNA)	NM_016604	NM_001081256 NM_029518
RefSeq (protein)	NP_057688	NP_001074725
Location (UCSC)	Chr 5: 138.35 – 138.44 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000120733 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Katoh M, Katoh M (Jun 2004). "Identification and characterization of JMJD2 family genes in silico". International Journal of Oncology. 24 (6): 1623–8. doi:10.3892/ijo.25.3.759. PMID 15138608.
5. "Entrez Gene: JMJD1B jumonji domain containing 1B".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Lai F, Godley LA, Fernald AA, Orelli BJ, Pamintuan L, Zhao N, Le Beau MM (Nov 2000). "cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins". Genomics. 70 (1): 123–30. doi:10.1006/geno.2000.6345. PMID 11087669.
• Lai F, Godley LA, Joslin J, Fernald AA, Liu J, Espinosa R, Zhao N, Pamintuan L, Till BG, Larson RA, Qian Z, Le Beau MM (Jan 2001). "Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q)". Genomics. 71 (2): 235–45. doi:10.1006/geno.2000.6414. PMID 11161817.
• Hu Z, Gomes I, Horrigan SK, Kravarusic J, Mar B, Arbieva Z, Chyna B, Fulton N, Edassery S, Raza A, Westbrook CA (Oct 2001). "A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31". Oncogene. 20 (47): 6946–54. doi:10.1038/sj.onc.1204850. PMID 11687974.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y (May 2006). "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor". Cell. 125 (3): 483–95. doi:10.1016/j.cell.2006.03.027. PMID 16603237.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• JMJD1B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.