HOXC8

Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.[5][6][7]

HOXC8
Identifiers
Aliases	HOXC8, HOX3, HOX3A, homeobox C8
External IDs	OMIM: 142970 MGI: 96198 HomoloGene: 130642 GeneCards: HOXC8
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 54,008,985 bp[1] End 54,012,769 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 58.05 cM Start 102,990,607 bp[2] End 102,994,111 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • microtubule cytoskeleton • cell nucleus • nucleoplasm Biological process • multicellular organism development • skeletal system morphogenesis • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • anterior/posterior pattern specification • neuron differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3224	15426
Ensembl	ENSG00000037965	ENSMUSG00000001657
UniProt	P31273	P09025
RefSeq (mRNA)	NM_022658	NM_010466
RefSeq (protein)	NP_073149	NP_034596
Location (UCSC)	Chr 12: 54.01 – 54.01 Mb	Chr 15: 102.99 – 102.99 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.[7] HOXC8 was found to have activity in promoting nerve growth and its expression is dysregulated in patients suffering from neurofibromatosis type 1.[8]

See also

• Homeobox

Interactions

HOXC8 has been shown to interact with Mothers against decapentaplegic homolog 6[9] and Mothers against decapentaplegic homolog 1.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000037965 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001657 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
6. Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
7. "Entrez Gene: HOXC8 homeobox C8".
8. Liu Y, Kang D, Li C, Xu G, Tan Y, Wang J (Jan 2014). "Microarray‑based identification of nerve growth‑promoting genes in neurofibromatosis type I". Mol Med Rep. 9 (1): 192–6. doi:10.3892/mmr.2013.1785. PMID 24213587.
9. Bai S, Shi X, Yang X, Cao X (March 2000). "Smad6 as a transcriptional corepressor". J. Biol. Chem. 275 (12): 8267–70. doi:10.1074/jbc.275.12.8267. PMID 10722652.
10. Shi X, Yang X, Chen D, Chang Z, Cao X (May 1999). "Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling". J. Biol. Chem. 274 (19): 13711–7. doi:10.1074/jbc.274.19.13711. PMID 10224145.

Further reading

• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (1989). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1989). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (1986). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9104–8. doi:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432.
• Simeone A, Mavilio F, Acampora D, Giampaolo A, Faiella A, Zappavigna V, D'Esposito M, Pannese M, Russo G, Boncinelli E (1987). "Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4914–8. doi:10.1073/pnas.84.14.4914. PMC 305217. PMID 2885844.
• Cannizzaro LA, Croce CM, Griffin CA, Simeone A, Boncinelli E, Huebner K (1987). "Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13". Am. J. Hum. Genet. 41 (1): 1–15. PMC 1684175. PMID 2886047.
• Lawrence HJ, Stage KM, Mathews CH, Detmer K, Scibienski R, MacKenzie M, Migliaccio E, Boncinelli E, Largman C (1993). "Expression of HOX C homeobox genes in lymphoid cells". Cell Growth Differ. 4 (8): 665–9. PMID 8104467.
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
• Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B (1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Lett. 415 (3): 263–7. doi:10.1016/S0014-5793(97)01118-6. PMID 9357979.
• Shi X, Yang X, Chen D, Chang Z, Cao X (1999). "Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling". J. Biol. Chem. 274 (19): 13711–7. doi:10.1074/jbc.274.19.13711. PMID 10224145.
• Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L (2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. doi:10.1074/jbc.275.1.147. PMID 10617598.
• Bai S, Shi X, Yang X, Cao X (2000). "Smad6 as a transcriptional corepressor". J. Biol. Chem. 275 (12): 8267–70. doi:10.1074/jbc.275.12.8267. PMID 10722652.
• Wan M, Shi X, Feng X, Cao X (2001). "Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression". J. Biol. Chem. 276 (13): 10119–25. doi:10.1074/jbc.M006918200. PMID 11139569.
• Schaefer LK, Wang S, Schaefer TS (2001). "Functional interaction of Jun and homeodomain proteins". J. Biol. Chem. 276 (46): 43074–82. doi:10.1074/jbc.M102552200. PMID 11551904.
• Waltregny D, Alami Y, Clausse N, de Leval J, Castronovo V (2002). "Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation". Prostate. 50 (3): 162–9. doi:10.1002/pros.10045. PMID 11813208.
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
• Bayarsaihan D, Enkhmandakh B, Makeyev A, Greally JM, Leckman JF, Ruddle FH (2003). "Homez, a homeobox leucine zipper gene specific to the vertebrate lineage". Proc. Natl. Acad. Sci. U.S.A. 100 (18): 10358–63. doi:10.1073/pnas.1834010100. PMC 193566. PMID 12925734.
• Luo L, Yang X, Takihara Y, Knoetgen H, Kessel M (2004). "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions" (PDF). Nature. 427 (6976): 749–53. doi:10.1038/nature02305. PMID 14973489.

External links

• HOXC8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.