USF1

Upstream stimulatory factor 1 is a protein that in humans is encoded by the USF1 gene.[5][6]

For the failed Formula One team, see US F1 Team.

USF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AN4
Identifiers
Aliases	USF1, FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11, upstream transcription factor 1
External IDs	OMIM: 191523 MGI: 99542 HomoloGene: 31426 GeneCards: USF1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,039,251 bp[1] End 161,045,977 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.4 cM Start 171,411,313 bp[2] End 171,419,142 bp[2]
Gene ontology Molecular function • DNA binding • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • histone deacetylase binding • bHLH transcription factor binding • GO:0001948 protein binding • protein heterodimerization activity • enzyme binding • double-stranded DNA binding • protein kinase binding • protein homodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • sequence-specific DNA binding • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0032403 macromolecular complex binding Cellular component • transcription factor complex • cell nucleus • nuclear chromatin • NURF complex • Set1C/COMPASS complex • nucleoplasm Biological process • carbon catabolite regulation of transcription • negative regulation of fibrinolysis • response to hypoxia • regulation of transcription, DNA-templated • glucose homeostasis • regulation of transcription from RNA polymerase II promoter • late viral transcription • transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter by glucose • glucose metabolic process • cellular response to insulin stimulus • positive regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter by glucose • lipid homeostasis • response to UV Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7391	22278
Ensembl	ENSG00000158773	ENSMUSG00000026641
UniProt	P22415	Q61069
RefSeq (mRNA)	NM_207005 NM_001276373 NM_007122	NM_009480 NM_001305676 NM_001305677 NM_001305678
RefSeq (protein)	NP_001263302 NP_009053 NP_996888	NP_001292605 NP_001292606 NP_001292607 NP_033506
Location (UCSC)	Chr 1: 161.04 – 161.05 Mb	Chr 1: 171.41 – 171.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the basic helix-loop-helix leucine zipper family and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

A study of mice suggested reduced USF1 levels increases metabolism in brown fat.[7]

Interactions

USF1 (human gene) has been shown to interact with USF2,[8][9] FOSL1[10] and GTF2I.[11][12]

References

1. GRCh38: Ensembl release 89: ENSG00000158773 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026641 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shieh BH, Sparkes RS, Gaynor RB, Lusis AJ (Apr 1993). "Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23". Genomics. 16 (1): 266–8. doi:10.1006/geno.1993.1174. PMID 8486371.
6. "Entrez Gene: USF1 upstream transcription factor 1".
7. Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, et al. (2016). "USF1 deficiency activates brown adipose tissue and improves cardiometabolic health". Science Translational Medicine. 8 (323): 323ra13. doi:10.1126/scitranslmed.aad0015. PMID 26819196.
8. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
9. Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.
10. Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889.
11. Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG (Dec 1997). "Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1". The EMBO Journal. 16 (23): 7091–104. doi:10.1093/emboj/16.23.7091. PMC 1170311. PMID 9384587.
12. Roy AL, Meisterernst M, Pognonec P, Roeder RG (Nov 1991). "Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF". Nature. 354 (6350): 245–8. doi:10.1038/354245a0. PMID 1961251.

Further reading

• Corre S, Galibert MD (Jan 2006). "[USF as a key regulatory element of gene expression]" (PDF). Médecine/Sciences. 22 (1): 62–7. doi:10.1051/medsci/200622162. PMID 16386222.
• Lee JC, Lusis AJ, Pajukanta P (Apr 2006). "Familial combined hyperlipidemia: upstream transcription factor 1 and beyond". Current Opinion in Lipidology. 17 (2): 101–9. doi:10.1097/01.mol.0000217890.54875.13. PMID 16531745.
• Roy AL, Meisterernst M, Pognonec P, Roeder RG (Nov 1991). "Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF". Nature. 354 (6350): 245–8. doi:10.1038/354245a0. PMID 1961251.
• Gregor PD, Sawadogo M, Roeder RG (Oct 1990). "The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer". Genes & Development. 4 (10): 1730–40. doi:10.1101/gad.4.10.1730. PMID 2249772.
• Henrion AA, Martinez A, Mattei MG, Kahn A, Raymondjean M (Jan 1995). "Structure, sequence, and chromosomal location of the gene for USF2 transcription factors in mouse". Genomics. 25 (1): 36–43. doi:10.1016/0888-7543(95)80107-W. PMID 7774954.
• Ferré-D'Amaré AR, Pognonec P, Roeder RG, Burley SK (Jan 1994). "Structure and function of the b/HLH/Z domain of USF". The EMBO Journal. 13 (1): 180–9. PMC 394791. PMID 8306960.
• Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.
• Ghosh AK, Datta PK, Jacob ST (Feb 1997). "The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo". Oncogene. 14 (5): 589–94. doi:10.1038/sj.onc.1200866. PMID 9053857.
• Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889.
• Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG (Dec 1997). "Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1". The EMBO Journal. 16 (23): 7091–104. doi:10.1093/emboj/16.23.7091. PMC 1170311. PMID 9384587.
• Pajukanta P, Nuotio I, Terwilliger JD, Porkka KV, Ylitalo K, Pihlajamäki J, Suomalainen AJ, Syvänen AC, Lehtimäki T, Viikari JS, Laakso M, Taskinen MR, Ehnholm C, Peltonen L (Apr 1998). "Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23". Nature Genetics. 18 (4): 369–73. doi:10.1038/ng0498-369. PMID 9537421.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Bengtsson SH, Madeyski-Bengtson K, Nilsson J, Bjursell G (Jul 2002). "Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2". The Biochemical Journal. 365 (Pt 2): 481–8. doi:10.1042/BJ20020223. PMC 1222691. PMID 11945176.
• Villavicencio EH, Yoon JW, Frank DJ, Füchtbauer EM, Walterhouse DO, Iannaccone PM (Apr 2002). "Cooperative E-box regulation of human GLI1 by TWIST and USF". Genesis. 32 (4): 247–58. doi:10.1002/gene.10078. PMID 11948912.
• Coulson JM, Edgson JL, Marshall-Jones ZV, Mulgrew R, Quinn JP, Woll PJ (Feb 2003). "Upstream stimulatory factor activates the vasopressin promoter via multiple motifs, including a non-canonical E-box". The Biochemical Journal. 369 (Pt 3): 549–61. doi:10.1042/BJ20021176. PMC 1223122. PMID 12403649.
• Salero E, Giménez C, Zafra F (Mar 2003). "Identification of a non-canonical E-box motif as a regulatory element in the proximal promoter region of the apolipoprotein E gene". The Biochemical Journal. 370 (Pt 3): 979–86. doi:10.1042/BJ20021142. PMC 1223214. PMID 12444925.
• Pickwell GV, Shih H, Quattrochi LC (Apr 2003). "Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation". Biochemical Pharmacology. 65 (7): 1087–96. doi:10.1016/S0006-2952(03)00037-6. PMID 12663044.

External links

• FactorBook USF1