CSDA (gene)

DNA-binding protein A is a protein that in humans is encoded by the CSDA gene.[5][6][7]

YBX3
Identifiers
Aliases	YBX3, CSDA, CSDA1, DBPA, ZONAB, Y-box binding protein 3
External IDs	OMIM: 603437 MGI: 2137670 HomoloGene: 2708 GeneCards: YBX3
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 10,699,089 bp[1] End 10,723,323 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F3 Start 131,364,855 bp[2] End 131,388,476 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001106 transcription corepressor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • mRNA 3'-UTR binding • single-stranded DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • nucleic acid binding • Rho GTPase binding • double-stranded DNA binding • RNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001948 protein binding • polysome binding Cellular component • polysome • bicellular tight junction • perinuclear region of cytoplasm • cell nucleus • cytoplasm • cytosol Biological process • male gonad development • regulation of transcription, DNA-templated • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • negative regulation of necroptotic process • positive regulation of cytoplasmic translation • cellular response to tumor necrosis factor • positive regulation of organ growth • negative regulation of apoptotic process • in utero embryonic development • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • cellular hyperosmotic response • negative regulation of skeletal muscle tissue development • spermatogenesis • response to cold • fertilization • 3'-UTR-mediated mRNA stabilization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8531	56449
Ensembl	ENSG00000060138	ENSMUSG00000030189
UniProt	P16989	Q9JKB3
RefSeq (mRNA)	NM_001145426 NM_003651	NM_011733 NM_139117
RefSeq (protein)	NP_001138898 NP_003642	NP_035863 NP_620817
Location (UCSC)	Chr 12: 10.7 – 10.72 Mb	Chr 6: 131.36 – 131.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000060138 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030189 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sakura H, Maekawa T, Imamoto F, Yasuda K, Ishii S (Jun 1989). "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology". Gene. 73 (2): 499–507. doi:10.1016/0378-1119(88)90514-8. PMID 2977358.
6. Coles LS, Diamond P, Occhiodoro F, Vadas MA, Shannon MF (Sep 1996). "Cold shock domain proteins repress transcription from the GM-CSF promoter". Nucleic Acids Res. 24 (12): 2311–7. doi:10.1093/nar/24.12.2311. PMC 145951. PMID 8710501.
7. "Entrez Gene: CSDA cold shock domain protein A".

Further reading

• Lloberas J, Soler C, Celada A (1998). "Repression mechanisms of the I-A beta gene of the major histocompatibility complex". Immunobiology. 198 (1–3): 249–63. doi:10.1016/s0171-2985(97)80045-9. PMID 9442396.
• Kudo S, Mattei MG, Fukuda M (1995). "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain". Eur. J. Biochem. 231 (1): 72–82. doi:10.1111/j.1432-1033.1995.tb20672.x. PMID 7628487.
• Funke B, Zuleger B, Benavente R, et al. (1996). "The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins". Nucleic Acids Res. 24 (19): 3821–8. doi:10.1093/nar/24.19.3821. PMC 146158. PMID 8871564.
• Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
• Hayashi J, Kajino K, Umeda T, et al. (2003). "Somatic mutation and SNP in the promoter of dbpA and human hepatocarcinogenesis". Int. J. Oncol. 21 (4): 847–50. doi:10.3892/ijo.21.4.847. PMID 12239625.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Coles LS, Bartley MA, Bert A, et al. (2004). "A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA. Potential role in mRNA stabilization". Eur. J. Biochem. 271 (3): 648–60. doi:10.1111/j.1432-1033.2003.03968.x. PMID 14728692.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Frankel P, Aronheim A, Kavanagh E, et al. (2005). "RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity". EMBO J. 24 (1): 54–62. doi:10.1038/sj.emboj.7600497. PMC 544910. PMID 15592429.
• Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Sourisseau T, Georgiadis A, Tsapara A, et al. (2006). "Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA". Mol. Cell. Biol. 26 (6): 2387–98. doi:10.1128/MCB.26.6.2387-2398.2006. PMC 1430269. PMID 16508013.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• CSDA+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human YBX3 genome location and YBX3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.